Optimization of the Ugi reaction using parallel synthesis and automated liquid handling
The Ugi reaction has proved to be a convenient way to quickly create diverse libraries of compounds. It involves the reaction of an amine, an aldehyde, a carboxylic acid and an isonitrile typically...
Received 27 August 2008 13:55 GMT; Posted 29 August 2008
Posted to: Chemistry, Pharmacology
Open Notebook Science – Falcipain-2 Preliminary Results
This talk was presented by Jean-Claude Bradley at the American Chemical Society meeting in Philadelphia on August 20, 2008. An introduction to Open Notebook Science is presented followed by an illu...
Received 21 August 2008 16:02 GMT; Posted 26 August 2008
Posted to: Chemistry, Bioinformatics
Chemistry Crowdsourcing and Open Notebook Science
This is a pre-proposal written for the NSF program CDI (Cyber-Enabled Discovery and Innovation) in Jan 2008.The current system of dissemination of scientific data and knowledge is far less efficie...
Received 09 January 2008 19:29 GMT; Posted 10 January 2008
Posted to: Cancer, Chemistry, Bioinformatics
The CombiUgi Project and Closing the Open Science Loop
This presentation combines 2 blog posts explaining the CombiUgi project and the predicted anti-tumor activity of a virtual library of 68,000 compounds.
Received 19 June 2007 16:23 GMT; Posted 20 June 2007
Posted to: Cancer, Chemistry, Bioinformatics
Open Notebook Science Using Blogs and Wikis
The first half is a summary of how the Bradley group at Drexel University is doing Open Notebook Science with the UsefulChem project to synthesize and test novel anti-malarial compounds. Graduate ...
Received 11 June 2007 20:23 GMT; Posted 12 June 2007
Posted to: Chemistry