http://precedings.nature.com/users/c5083b542c60f0db75291a01f45baef5/ Documents posted by Duncan Legge Nature Publishing Group en Nature Precedings http://precedings.nature.com/images/header_logo.gif http://precedings.nature.com http://dx.doi.org/10.1038/npre.2009.3157.1 The nematode worm, Caenorhabditis elegans, was the first multicellular organism to be sequenced. Its genome was published in 1998, providing an impetus for gene and protein annotation. Recently, the genome of C. briggsae has been sequenced. This has given bioinformaticans the opportunity to study comparative genomics between two highly similar organisms. Currently, there are 12 species of Caenorhabditis in UniProtKB and over 700 nematode species, including some of interest to parasitology. Functional and sequence annotation from literature and sequence analysis tools are included in each curated record. C. elegans has a relatively small genome size, short life span and a transparent body, making it ideal for knock-out/RNAi studies. Thus many C. elegans UniProtKB entries have characterization details in the newly introduced DISRUPTION PHENOTYPE comment. Many more worm genome sequencing projects are underway, three of which involve species from the Caenorhabditis genus (C. brenneri, C. japonica and C.remanei). We look forward to working with this influx of data and continuing our close collaboration with WormBase. http://dx.doi.org/10.1038/npre.2009.3157.1 Thu, 23 Apr 2009 17:20:07 UTC Worm Annotation in the UniProt Knowledgebase (UniProtKB) doi:10.1038/npre.2009.3157.1 2009-04-23 Duncan J. Legge Nature Precedings 2009-04-23T17:20:07Z Poster Bioinformatics http://creativecommons.org/licenses/by/3.0/