http://precedings.nature.com/users/c428296def05423b48b8358962b25a32/ Documents posted by chao tian Nature Publishing Group en Nature Precedings http://precedings.nature.com/images/header_logo.gif http://precedings.nature.com http://precedings.nature.com/documents/3254/version/2 Two recent genome-wide association studies have described associations of SNP variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels in population based cohorts. We investigated the contributions of these variants to clinical outcomes in Mestizo subjects with a history of excessive alcohol consumption. We show that non-synonymous variant rs738409[G] (I148M) in PNPLA3 is strongly associated with alcoholic liver disease and progression to alcoholic cirrhosis (unadjusted OR = 2.25, P = 1.7×10-10; ancestry-adjusted OR = 1.79, P = 1.9×10-5). http://precedings.nature.com/documents/3254/version/2 Tue, 06 Oct 2009 09:39:45 UTC Variation in PNPLA3 is associated with outcomes in alcoholic liver disease hdl:10101/npre.2009.3254.2 2009-10-06 David A. Hinds Nature Precedings 2009-10-06T09:39:45Z Manuscript Genetics & Genomics http://creativecommons.org/licenses/by/3.0/