Mohane Coumar
3 votes
Structure-based design of novel pyrazoles as aurora kinase A inhibitors.
Inhibition of Aurora kinase, a member of serine/threonine kinase involved in the regulation of cell division is emerging as a new molecular targeted cancer treatment option. Three isoforms of Auror…
Received 10 January 2009 02:52 UTC; Posted 12 January 2009
Posted to: Biotechnology, Cancer, Chemistry
1 vote
Down-regulation of Survivin enhances sensitivity to BPR0L075 in human cancer cells via caspase-independent mechanisms
Background: BPR0L075 [6-methoxy-3-(3’,4’,5’-trimethoxy-benzoyl)-1H-indole] is a novel anti-cancer compound. It inhibits tubulin polymerization and induces mitochondrial-dependent apoptosis in vario…
Received 29 December 2008 09:16 UTC; Posted 29 December 2008
Posted to: Cancer
