Alessandra Pani
In vitro synergistic anti-prion effect of cholesterol ester modulators
Background. Our studies on the role of cholesterol in prion infection/replication showed that brains and peripheral cells of sheep susceptible to or suffering from Scrapie were characterized by an …
Received 21 October 2009 13:06 UTC; Posted 21 October 2009
Posted to: Microbiology, Neuroscience, Pharmacology
Altered cholesterol ester cycle in ex vivo skin fibroblasts from Alzheimer patients
Recent studies in both animal and cell models of Alzheimer’s disease (AD) indicated that sub-cellular cholesterol distribution seems to regulate amyloid-beta (Aβ) generation in the brain. In p…
Received 18 February 2008 17:15 UTC; Posted 19 February 2008
Posted to: Molecular Cell Biology, Neuroscience
Changes in Cholesterol Metabolism in Peripheral Cells of Alzheimer Disease Patients and Their Relatives
Background. Previous epidemiological and experimental studies indicated cholesterol as a central player in Alzheimer disease (AD). Here, we utilized skin fibroblasts and PBMC as possible ex vivo m…
Received 23 October 2007 08:02 UTC; Posted 08 November 2007
Posted to: Molecular Cell Biology, Neuroscience
ACAT1, Cav-1, and PrP expression in brains and skin fibroblasts from Sarda breed sheep with scrapie-resistant and scrapie-susceptible genotype.
Scrapie is an infective ovine neurodegenerative disease; the only identified component of the infectious agent being an aberrant isoform (PrPSc) of the cellular prion protein (PrPC). So far, no mea…
Received 08 October 2007 10:02 UTC; Posted 09 October 2007
Posted to: Molecular Cell Biology
