http://precedings.nature.com/users/82fa1c7cc981ed97dc704439b89975b9/ Documents posted by Ahmed Esmaeel Nayel Nature Publishing Group en Nature Precedings http://precedings.nature.com/images/header_logo.gif http://precedings.nature.com http://precedings.nature.com/documents/743/version/2 The rapid evolution of the H5N1 serotype of avian influenza has been explained by a mechanism involving the selection of single nucleotide polymorphisms generated by copy errors. The recent emergence of H5N1 Clade 2.2 in fifty countries, offered a unique opportunity to view the acquisition of new polymorphism in these evolving genomes. We analyzed the H5N1 hemagglutinin gene from a fatal human case from Nigeria in 2007. The newly emerged polymorphisms were present in diverse H5N1 isolates from the previous year. The aggregation of these polymorphisms from clade 2.2 sub-clades was not supported by recent random mutations, and was most easily explained by recombination between closely related sequences. http://precedings.nature.com/documents/743/version/2 Wed, 12 Sep 2007 11:04:26 UTC Aggregation of Single Nucleotide Polymorphisms in a Human H5N1 Clade 2.2 Hemagglutinin hdl:10101/npre.2007.743.2 2009-03-04 Henry L. Niman Nature Precedings 2007-09-12T11:04:26Z Manuscript Genetics & Genomics Evolutionary Biology http://creativecommons.org/licenses/by/2.5/