Michael Baker
Independent elaboration of steroid hormone signaling pathways in Metazoans
Steroid hormones regulate many physiological processes in vertebrates, nematodes and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcripti…
Received 25 June 2009 20:55 UTC; Posted 26 June 2009
Posted to: Cancer, Developmental Biology, Bioinformatics, Earth & Environment, Evolutionary Biology
3D model of amphioxus steroid receptor complexed with estradiol
The origins of signaling by vertebrate steroids are not fully understood. An important advance was the report that an estrogen-binding steroid receptor [SR] is present in amphioxus, a basal chorda…
Received 03 June 2009 21:14 UTC; Posted 05 June 2009
Posted to: Cancer, Developmental Biology, Bioinformatics, Evolutionary Biology
Motif analysis of amphioxus, lamprey and invertebrate estrogen receptors and amphioxus and human estrogen-related receptors: Towards a better understanding of estrogen receptor evolution
Background. The origins of steroid-dependent regulation of the vertebrate estrogen receptor (ER) are poorly understood. Genes with statistically significant sequence similarity to vertebrate ER…
Received 11 April 2008 21:28 UTC; Posted 14 April 2008
Posted to: Cancer, Developmental Biology, Ecology, Evolutionary Biology
Analysis of Endocrine Disruption in Southern California Coastal Fish using an Aquatic Multi-Species Microarray
BACKGROUND: Endocrine disruptors include plasticizers, pesticides, detergents and pharmaceuticals. Turbot and other flatfish are used to characterize the presence of chemicals in the marine envir…
Received 28 January 2009 02:08 UTC; Posted 02 February 2009
Posted to: Developmental Biology, Ecology, Genetics & Genomics, Earth & Environment
3D model of lamprey estrogen receptor with estradiol and 15α-hydroxy-estradiol
Lamprey, a basal vertebrate, contains orthologs of the estrogen receptor (ER), progesterone receptor and corticoid receptor. A perplexing property of lamprey is that 15α-hydroxy-steroids are…
Received 09 January 2009 02:16 UTC; Posted 09 January 2009
Posted to: Developmental Biology, Ecology, Earth & Environment
Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11β-hydroxysteroid dehydrogenase 1
Intracellular glucocorticoid reactivation is catalyzed by 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), which functions predominantly as a reductase in cells expressing hexose-6-phosphat…
Received 22 October 2008 18:32 UTC; Posted 22 October 2008
Posted to: Molecular Cell Biology, Pharmacology, Bioinformatics
Dibutyltin Disrupts Glucocorticoid Receptor Function and Impairs Glucocorticoid-induced Suppression of Cytokine Production
Background. Organotins are highly toxic and widely distributed environmental chemicals. Dibutyltin (DBT) is used as stabilizer in the production of polyvinyl chloride plastics, and it is also the…
Received 18 September 2008 19:55 UTC; Posted 19 September 2008
Posted to: Immunology, Pharmacology, Bioinformatics
Trichoplax, the simplest known animal, contains an estrogen-related receptor but no estrogen receptor: Implications for estrogen receptor evolution
Although, as their names imply, estrogen receptors [ERs] and estrogen-related receptors [ERRs] are related transcription factors, their evolutionary relationships to each other are not fully unders…
Received 12 August 2008 02:08 UTC; Posted 13 August 2008
Posted to: Developmental Biology, Ecology, Evolutionary Biology
Trichoplax, the simplest known animal, contains an estrogen-related receptor: Implications for the evolution of vertebrate and invertebrate estrogen receptors
Although, as their names imply, vertebrate and invertebrate estrogen receptors [ERs] and estrogen-related receptors [ERRs] are related transcription factors, their evolutionary relationships to eac…
Received 06 May 2008 21:45 UTC; Posted 06 May 2008
Posted to: Developmental Biology, Ecology, Evolutionary Biology
