Leonid Mirny
Nucleosome-mediated cooperativity between transcription factors
Cooperative binding of transcription factors (TFs) to cis-regulatory regions (CRRs) is essential for precision of gene expression in development and other processes. The classical model of cooperat…
Received 16 January 2009 23:21 UTC; Posted 21 January 2009
Posted to: Developmental Biology, Genetics & Genomics, Molecular Cell Biology, Bioinformatics
Fundamentally different strategies for transcriptional regulation are revealed by analysis of binding motifs
To regulate a particular gene, a transcription factor (TF) needs to bind a specific genome location. How is this genome address specified amid the presence of ~106-109 decoy sites? Our analysis…
Received 27 December 2008 20:53 UTC; Posted 28 December 2008
Posted to: Genetics & Genomics, Molecular Cell Biology, Bioinformatics, Evolutionary Biology
An optimized energy potential can predict SH2 domain-peptide interactions
Peptide recognition modules (PRMs) are used throughout biology to mediate protein-protein interactions, and many PRMs are members of large protein domain families. Members of these families are of…
Received 12 May 2008 20:23 UTC; Posted 12 May 2008
Posted to: Molecular Cell Biology, Bioinformatics
