Connecting Seed Lists of Mammalian Proteins Using Steiner Trees
Multivariate experiments and genomics studies applied to mammalian cells often produce lists of genes or proteins altered under treatment/disease vs. control/normal conditions. Such lists can be id...
Received 05 April 2008 20:50 GMT; Posted 07 April 2008
Posted to: Biotechnology, Cancer, Molecular Cell Biology, Bioinformatics
Systems Pharmacology
The slides are from a presentation given by Professor Ravi Iyengar from Mount Sinai School of Medicine at the Drug Forum Meeting #9 that took place in Washington, DC on February 20-21, 2008. The sl...
Received 01 April 2008 16:12 GMT; Posted 02 April 2008
Posted to: Biotechnology, Chemistry, Pharmacology, Bioinformatics
Genes2Networks: Connecting Lists of Proteins by Using Background Literature-based Mammalian Networks
In recent years, in-silico literature-based mammalian protein-protein interaction network datasets have been developed. These datasets contain binary interactions extracted manually from legacy exp...
Received 07 June 2007 15:27 GMT; Posted 08 June 2007
Posted to: Biotechnology, Molecular Cell Biology, Bioinformatics
Intracellular Regulatory Networks are close to Monotone Systems
Several meso-scale biological intracellular regulatory networks that have specified directionality of interactions have been recently assembled from experimental literature. Directed networks where...
Received 23 January 2007 16:57 GMT; Posted 23 January 2007
Posted to: Molecular Cell Biology, Bioinformatics
Dynamic Topology of Biological Networks
The mammalian cell can be represented as a large modular network that consists of a central signal network that interacts with and regulates multiple cellular machines that are responsible for phen...
Received 23 January 2007 16:48 GMT; Posted 23 January 2007
Posted to: Molecular Cell Biology, Neuroscience, Pharmacology, Bioinformatics