Charlie Chandsawangbhuwana
Motif analysis of amphioxus, lamprey and invertebrate estrogen receptors and amphioxus and human estrogen-related receptors: Towards a better understanding of estrogen receptor evolution
Background. The origins of steroid-dependent regulation of the vertebrate estrogen receptor (ER) are poorly understood. Genes with statistically significant sequence similarity to vertebrate ER…
Received 11 April 2008 21:28 UTC; Posted 14 April 2008
Posted to: Cancer, Developmental Biology, Ecology, Evolutionary Biology
3D model of lamprey estrogen receptor with estradiol and 15α-hydroxy-estradiol
Lamprey, a basal vertebrate, contains orthologs of the estrogen receptor (ER), progesterone receptor and corticoid receptor. A perplexing property of lamprey is that 15α-hydroxy-steroids are…
Received 09 January 2009 02:16 UTC; Posted 09 January 2009
Posted to: Developmental Biology, Ecology, Earth & Environment
Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11β-hydroxysteroid dehydrogenase 1
Intracellular glucocorticoid reactivation is catalyzed by 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), which functions predominantly as a reductase in cells expressing hexose-6-phosphat…
Received 22 October 2008 18:32 UTC; Posted 22 October 2008
Posted to: Molecular Cell Biology, Pharmacology, Bioinformatics
Dibutyltin Disrupts Glucocorticoid Receptor Function and Impairs Glucocorticoid-induced Suppression of Cytokine Production
Background. Organotins are highly toxic and widely distributed environmental chemicals. Dibutyltin (DBT) is used as stabilizer in the production of polyvinyl chloride plastics, and it is also the…
Received 18 September 2008 19:55 UTC; Posted 19 September 2008
Posted to: Immunology, Pharmacology, Bioinformatics
