Submissions tagged with transcription
(10 documents)
9aaTADs mimic DNA to interact with a pseudo-DNA Binding Domain KIX of Med15 (Molecular Chameleons)
The KIX-domain of Gal11/MED15 was shown to interact with short transactivation domain of Pdr1 and Oaf1 (12 and 9 amino acids respectively) annotated to 9aaTAD family. Reported NMR data revealed a s…
Received 03 November 2009 21:11 UTC; Posted 05 November 2009
Posted to: Genetics & Genomics
Common Transactivation Motif 9aaTAD recruits multiple general co-activators TAF9, MED15, CBP and p300
More than 2000 transcription factors are involved in the human gene regulation to provide cellular function and development. Transactivation domain, TAD, mediates the interaction of transcription f…
Received 03 November 2009 12:30 UTC; Posted 05 November 2009
Posted to: Genetics & Genomics
A coordinated phosphorylation cascade initiated by MSK1 directs RAR alpha recruitment to target gene promoters
The nuclear retinoic acid (RA) receptor alpha (RARα) is a transcriptional transregulator that controls the expression of specific gene subsets through binding at response elements and dynami…
Received 22 July 2008 17:03 UTC; Posted 23 July 2008
Posted to: Molecular Cell Biology
A Genome-Wide Analysis Reveals Significant Overlap of Transcription and DNA Repair in Stationary Phase Yeast
The association between transcription and DNA repair is acknowledged as a player in the generation of mutations in a non-random fashion in prokaryotes and eukaryotes. Previous studies demonstrated …
Received 27 January 2008 20:07 UTC; Posted 28 January 2008
Posted to: Genetics & Genomics, Evolutionary Biology
c-Myc induced changes in higher order rDNA structure accompany growth factor stimulation of quiescent cells
Human c-Myc is believed to be a high level coordinator of protein synthesis capacity and cell growth rate, capable of activating transcription by all three nuclear RNA Polymerases. Direct activatio…
Received 21 December 2007 16:35 UTC; Posted 24 December 2007
Posted to: Genetics & Genomics
Discovery of transcription factor binding sites through integration of generic motif finders
Locating transcription factor binding sites is a key step in understanding gene regulation. Due to its importance, many de novo motif-finding methods have been proposed. Individually, these motif…
Received 25 October 2007 09:49 UTC; Posted 25 October 2007
Posted to: Biotechnology, Bioinformatics
Upstream Stimulatory Factor (USF) and CCAAT/Enhancer Binding Protein δ (C/EBPδ) Compete for overlapping Sites in the Negative Regulatory Region of the HIV-1 LTR
Human immunodeficiency virus type 1 (HIV-1) is a human retrovirus and the causative agent of the acquired immunodeficiency syndrome. Genetic analysis has revealed that the HIV-1 LTR contains a pote…
Received 08 October 2007 15:49 UTC; Posted 09 October 2007
Posted to: Immunology, Molecular Cell Biology
Activation of TRF3 Transcription Factor by Small Interfering RNAs
RNA interference (RNAi) is a conserved biological response to double-stranded RNAs that results in posttranscriptional silencing of target gene expression. Double-stranded processed RNAs of 21-23 n…
Received 04 October 2007 06:58 UTC; Posted 04 October 2007
Posted to: Molecular Cell Biology
Kinase independent inhibition of NFκB transcriptional activity by GRK5 through IκBα stabilization.
Members of the G protein receptor kinase (GRK) family that regulates receptor desensitization and members of the nuclear transcription factors family NFκB have been recently and convincingly …
Received 29 September 2007 07:20 UTC; Posted 01 October 2007
Posted to: Immunology, Molecular Cell Biology
PIM1-dependent phosphorylation of Histone H3 at Serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation.
The serine/threonine kinase PIM1, cooperates with MYC in cell cycle progression and tumorigenesis. However, the nature of this cooperation remains elusive. Here we show that PIM1 contributes to the…
Received 19 June 2007 14:34 UTC; Posted 20 June 2007
Posted to: Cancer, Molecular Cell Biology
