Submissions tagged with systems biology
(14 documents)
Embedding machine-readable proteins interactions data in scientific articles for easy access and retrieval
Extraction of protein-protein interactions data from scientific literature remains a hard, time- and resource-consuming task. This task would be greatly simplified by embedding in the source, i.e. ...
Received 29 September 2008 14:13 GMT; Posted 01 October 2008
Posted to: Bioinformatics
Systems Biology Graphical Notation: Process Diagram Level 1
Standard graphical representations have played a crucial role in science and engineering throughout the last century. Without electrical symbolism, it is very likely that our industrial society wou...
Received 22 September 2008 20:24 GMT; Posted 23 September 2008
Posted to: Biotechnology, Bioinformatics
A network-based signaling mechanism of cancer development and progression
We conducted a comprehensive analysis of a manually curated human signaling network containing 1634 nodes and 5089 signaling regulatory relations by integrating cancer-associated genetically and ep...
Received 27 August 2008 18:57 GMT; Posted 27 August 2008
Posted to: Cancer, Genetics, Bioinformatics
Building Block and Building Rule: Dual Descriptor Method for Biological Sequence Analysis
The emergence of “Systems Biology” in recent years highlights the systematic viewpoint of bio-system modeling. Building on such a background, Dual Descriptor Method, a generic methodology for biolo...
Received 23 August 2008 17:45 GMT; Posted 26 August 2008
Posted to: Biotechnology, Bioinformatics
GabiPD: GABI primary database – a plant integrative ‘omics’ database
The GABI Primary Database, GabiPD, was established eight years ago in the frame of the German initiative for Genome Analysis of the Plant Biological System (Genomanalyse im biologischen System Pfla...
Received 22 August 2008 09:56 GMT; Posted 22 August 2008
Posted to: Bioinformatics
Systems Pharmacology
The slides are from a presentation given by Professor Ravi Iyengar from Mount Sinai School of Medicine at the Drug Forum Meeting #9 that took place in Washington, DC on February 20-21, 2008. The sl...
Received 01 April 2008 16:12 GMT; Posted 02 April 2008
Posted to: Biotechnology, Chemistry, Pharmacology, Bioinformatics
Systems Biology Markup Language (SBML) Level 2: Structures and Facilities for Model Definitions
With the rise of Systems Biology as a new paradigm for understanding biological processes, the development of quantitative models is no longer restricted to a small circle of theoreticians. The dra...
Received 26 October 2007 08:21 GMT; Posted 05 November 2007
Posted to: Bioinformatics
Intracellular Regulatory Networks are close to Monotone Systems
Several meso-scale biological intracellular regulatory networks that have specified directionality of interactions have been recently assembled from experimental literature. Directed networks where...
Received 23 January 2007 16:57 GMT; Posted 23 January 2007
Posted to: Molecular Cell Biology, Bioinformatics
Dynamic Topology of Biological Networks
The mammalian cell can be represented as a large modular network that consists of a central signal network that interacts with and regulates multiple cellular machines that are responsible for phen...
Received 23 January 2007 16:48 GMT; Posted 23 January 2007
Posted to: Molecular Cell Biology, Neuroscience, Pharmacology, Bioinformatics
The Systems Biology Markup Language (SBML): Where It’s Been and Where It’s Going
A cornerstone of systems biology is the use of computational modeling, by which hypotheses can be cast into a quantitative form that can be tested systematically. The use of computational modeling...
Received 22 January 2007 04:39 GMT; Posted 22 January 2007
Posted to: Biotechnology, Bioinformatics