Submissions tagged with statistics
(6 documents)
Parallel routes of human carcinoma development: Implications of the age-specific incidence data
The multi-stage hypothesis suggests that cancers develop through a single defined series of genetic alterations. This hypothesis was first suggested over 50 years ago based upon age-specific incide…
Received 17 April 2009 18:14 UTC; Posted 17 April 2009
Posted to: Cancer, Genetics & Genomics
The Gloomy Prospect Wins: Statistical Significance and Population Stratification in Genome Wide Association Studies
This one-hour lecture by Dr. Eric Turkheimer of the University of Virginia’s Department of Psychology explored the following:The contemporary era has seen a convergence of genomic technology a…
Received 12 December 2008 00:35 UTC; Posted 15 December 2008
Posted to: Genetics & Genomics
Significance tests for comparing digital gene expression profiles
Most of the statistical tests currently used to detect differentially expressed genes are based on asymptotic results, and perform poorly for low expression tags. Another problem is the common us…
Received 28 August 2008 14:08 UTC; Posted 29 August 2008
Posted to: Genetics & Genomics, Bioinformatics
The Normal Fetal Heart Rate Study: Analysis Plan
Recording of fetal heart rate via CTG monitoring has been routinely performed as an important part of antenatal and subpartum care for several decades. The current guidelines of the FIGO (ref1) rec…
Received 29 October 2007 12:39 UTC; Posted 12 November 2007
Posted to: Bioinformatics
Effective Sample Size: Quick Estimation of the Effect of Related Samples in Genetic Case-Control Association Analyses
Correlated samples have been frequently avoided in case-controlgenetic association studies in part because the methods for handling them are either noteasily implemented or not widely known….
Received 09 July 2007 21:41 UTC; Posted 10 July 2007
Posted to: Genetics & Genomics, Immunology
The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies
Reproducibility is a fundamental requirement in scientific experiments and clinical contexts. Recent publications raise concerns about the reliability of microarray technology because of the appar…
Received 02 July 2007 15:49 UTC; Posted 03 July 2007
Posted to: Biotechnology, Bioinformatics
