Submissions tagged with microarray
(18 documents)
Genome-wide transcription analysis of interaction between the human macrophage and Mycobacterium tuberculosis during concurrent drug administration by conventional and novel methods
Targeted drug delivery to alveolar macrophages harboring Mycobacterium tuberculosis (Mtb) holds promise of high efficacy against pulmonary tuberculosis (TB). It was investigated whether inhalable m…
Received 31 October 2008 05:43 UTC; Posted 04 November 2008
Posted to: Pharmacology
Affymetrix probes containing runs of contiguous guanines are not gene-specific
High Density Oligonucleotide arrays (HDONAs), such as the Affymetrix HG-U133A GeneChip, use sets of probes chosen to match specified genes, with the expectation that if a particular gene is highly …
Received 22 April 2008 10:54 UTC; Posted 22 April 2008
Posted to: Biotechnology, Bioinformatics
Intra- and inter-individual genetic differences in gene expression
Genetic variation is known to influence the amount of mRNA produced by a gene. Given that the molecular machines control mRNA levels of multiple genes, we expect genetic variation in the components…
Received 15 April 2008 01:17 UTC; Posted 15 April 2008
Posted to: Genetics & Genomics, Bioinformatics
Systemic similarity analysis of compatibility drug-induced multiple pathway patterns in vivo
A major challenge in post-genomic research is to understand how physiological and pathological phenotypes arise from the networks of expressed genes and to develop powerful tools for translating th…
Received 15 March 2008 08:15 UTC; Posted 17 March 2008
Posted to: Neuroscience, Pharmacology
A novel class of endogenous shRNAs in human cells
Until now it is still not clear how many types and amounts of small RNAs (sRNAs) exist in humans. Here we report the identification of 1258 distinct sRNAs derived from intronic regions of protein-c…
Received 22 January 2008 09:16 UTC; Posted 23 January 2008
Posted to: Biotechnology
ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes
ChIP-on-chip has emerged as a powerful tool to dissect the complex network of regulatory interactions between transcription factors and their targets. However, most ChIP-on-chip analysis methods us…
Received 26 November 2007 20:49 UTC; Posted 28 November 2007
Posted to: Cancer, Genetics & Genomics, Bioinformatics
Diagnostic robustness of DNA microarrays in the classification of acute leukemia
Countless statistical methods have been described for the analysis of DNA microarrays, and each yields distinct results. This raises the question whether DNA microarrays are robust diagnostic tools…
Received 20 September 2007 15:34 UTC; Posted 26 September 2007
Posted to: Biotechnology, Cancer, Genetics & Genomics, Molecular Cell Biology, Pharmacology, Bioinformatics
DNA expression microarrays may be the wrong tool to identify biological pathways
DNA microarray expression signatures are expected to provide new insights into patho- physiological pathways. Numerous variant statistical methods have been described for each step of the signal an…
Received 18 September 2007 13:09 UTC; Posted 19 September 2007
Posted to: Biotechnology, Genetics & Genomics, Molecular Cell Biology, Pharmacology, Bioinformatics
