Submissions tagged with immunity
(2 documents)
1 vote
Deficiency of interleukin-1 receptor antagonist causes spontaneous femoral artery aneurysms
Interleukin (IL) -1, a proinflammatory cytokine, increases in aneurysm, and the IL-1 receptor antagonist (IL-1Ra) modulates IL-1 activity endogenously. We show here that IL-1Ra-deficiency in hemato…
Received 28 January 2009 15:07 UTC; Posted 29 January 2009
Posted to: Molecular Cell Biology
4 votes
CD14 Modulates PI3K/AKT/p38-MAPK Licensing of Negative Regulators of TLR Signaling to Restrain Chronic Inflammation
Current thinking emphasizes the primacy of CD14 in facilitating TLR recognition of microbes to initiate proinflammatory signaling events and the importance of p38-MAPK in augmenting such responses….
Received 24 June 2008 18:09 UTC; Posted 25 June 2008
Posted to: Immunology, Microbiology
