Submissions tagged with gene therapy
(8 documents)
Enhanced anti-tumor effects of combined MDR1 RNA interference and human sodium/iodide symporter (NIS) radioiodine gene therapy using an adenoviral system in a colon cancer model
Using an adenoviral system as a delivery mediator of therapeutic gene, we investigated the therapeutic effects of the use of combined MDR1 shRNA and human NIS (hNIS) radioiodine gene therapy in…
Received 02 June 2009 13:12 UTC; Posted 02 June 2009
Posted to: Cancer
Heat shock transcription factor 1 preserves cardiac angiogenesis and adaptation during pressure overload
To examine how heat shock transcription factor 1 (HSF1) protects against maladaptive hypertrophy during pressure overload, we subjected HSF1 transgenic (TG), knockout (KO) and wild type (WT) mice t…
Received 24 December 2008 13:51 UTC; Posted 24 December 2008
Posted to: Molecular Cell Biology
Adenovirus-mediated transfer of siRNA against survivin enhances the radiosensitivity of human non-small cell lung cancer cells
Expression of survivin has been reported to be correlated with shorter survival in patients with non-small cell lung cancer (NSCLC), and overexpression of survivin may lead to radioresistance in va…
Received 01 December 2008 17:22 UTC; Posted 02 December 2008
Posted to: Cancer, Molecular Cell Biology
Gene Transfer of Calcitonin Gene-Related Peptide Inhibits Macrophages and Inflammatory Mediators in Vein Graft Disease
Vein graft disease is a chronic inflammatory disease and limits the late results of coronary revascularization. Calcitonin gene-related peptide (CGRP) inhibits macrophages infiltrated and inflammat…
Received 31 October 2008 18:14 UTC; Posted 06 November 2008
Posted to: Molecular Cell Biology
pFAR plasmids: New Eukaryotic Expression Vectors for Gene Therapy, devoid of Antibiotic Resistance Markers
Efficient production of eukaryotic expression vectors requires the selection of plasmid-containing bacteria. To avoid the risk of dissemination of antibiotic resistance markers, we developed a new …
Received 13 October 2008 09:15 UTC; Posted 17 October 2008
Posted to: Biotechnology, Genetics & Genomics
Efficient polyethylenimine-mediated gene delivery proceeds via a caveolar pathway in HeLa cells.
Most in vivo gene therapies will require cell-specific targeting. Although vector targeting through ligand attachment has met with success in generating gene delivery particles that are capable of …
Received 05 September 2008 17:33 UTC; Posted 08 September 2008
Posted to: Biotechnology, Cancer
The effects of anti-sense interleukin-5 gene transferred by recombinant adeno-associated virus in allergic rats
The accumulation and infiltration of eosinophils in airways is one of the most important characteristics of asthma, and is mediated partly by secretion of IL-5 from Th2 lymphocytes. It is well know…
Received 03 July 2008 06:19 UTC; Posted 09 July 2008
Posted to: Biotechnology, Molecular Cell Biology
Novel Cell type-specific aptamer-siRNA delivery system for HIV-1 therapy
The successful use of small interfering RNAs (siRNAs) for therapeutic purposes requires safe and efficient delivery to specific cells and tissues. Here we demonstrate cell type-specific delivery of…
Received 08 November 2007 20:57 UTC; Posted 14 November 2007
Posted to: Biotechnology, Molecular Cell Biology
