Submissions tagged with cancer
(19 documents)
The Broad Spectrum HDAC Inhibitor PCI-24781 Induces Caspase- and ROS-Dependent Apoptosis and is Synergistic with Bortezomib in Lymphoma
We investigated the cytotoxicity and biology of the novel broad-spectrum hydroxamic acid-based histone deacetylase inhibitor (HDACi), PCI-24781. PCI-24781 was studied alone and combined with bortez…
Received 23 June 2008 15:46 UTC; Posted 12 July 2008
Posted to: Cancer, Pharmacology
Serum profiling and biomarker discovery of rat mammary tumors using mass-coded abundance tags (MCAT)
Advances in Mass-spectrometry techniques allow for the rapid processing and evaluation of complex biological mixtures such as blood/serum. These samples represent a protein rich environment as well…
Received 02 July 2008 20:52 UTC; Posted 03 July 2008
Posted to: Cancer
Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanisms.
PPP1R13L was initially identified as a protein that binds to the NF-κB subunit p65/RelA and inhibits its transcriptional activity. It also binds p53 and inhibits its action. One set of experi…
Received 24 June 2008 16:03 UTC; Posted 24 June 2008
Posted to: Cancer
14-3-3ζ is Amplified, Overexpressed and Possesses Oncogenic Activities in Head and Neck Squamous Cell Carcinoma
Gene amplification, a common mechanism for oncogene activation in cancers, has been used in the discovery of novel oncogenes. DNA amplification is frequently observed in head and neck squamous cell…
Received 06 June 2008 20:46 UTC; Posted 09 June 2008
Posted to: Cancer
Potential role of 2,2’-biphenylquinones in the carcinogenic/anti-cancer activity of dioxins
Modes of carcinogenicity for the well-known environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been investigated over the past several decades. However, the mechanisms underl…
Received 30 May 2008 03:57 UTC; Posted 31 May 2008
Requirement of RIZ1 for cancer prevention by methyl-balanced diet
The typical Western diet is not balanced in methyl nutrients that regulate the level of the methyl donor S-adenosylmethionine (SAM) and its derivative metabolite S-adenosylhomocysteine (SAH), which…
Received 27 March 2008 17:58 UTC; Posted 28 March 2008
Posted to: Cancer, Genetics & Genomics
Iridium complex, a phosphorescent light-emitting diode material, serves as a novel chemical probe for imaging hypoxic tumor tissues
Iridium complex, a promising organic light-emitting diode for next generation television displays, emits phosphorescence. Phosphorescence is quenched by oxygen. We used this oxygen-quenching featur…
Received 19 December 2007 23:59 UTC; Posted 20 December 2007
Posted to: Biotechnology, Cancer, Chemistry
Diagnostic robustness of DNA microarrays in the classification of acute leukemia
Countless statistical methods have been described for the analysis of DNA microarrays, and each yields distinct results. This raises the question whether DNA microarrays are robust diagnostic tools…
Received 20 September 2007 15:34 UTC; Posted 26 September 2007
Posted to: Biotechnology, Cancer, Genetics & Genomics, Molecular Cell Biology, Pharmacology, Bioinformatics
Opposite effects of two zinc(II) dithiocarbamates on NF-kB pathway
Inhibiting nuclear factor-kappaB (NF-kB) activation in anticancer and antiinflammatory therapy is of topical interest. Current research in molecular biology has dramatically advanced in the underst…
Received 15 August 2007 11:21 UTC; Posted 16 August 2007
Posted to: Cancer, Chemistry, Molecular Cell Biology, Pharmacology
