Submissions tagged with autoimmunity
(2 documents)
IL-1 regulates the IL-23 response to wheat gliadin, the etiologic agent of Celiac Disease
Celiac disease (CD) is an autoimmune disease prevalent in ~1% of the general population. CD is unique because both the major genetic (Human Leukocyte Antigen-DQ2/DQ8 alleles) and etiologic factors ...
Received 13 May 2008 16:47 GMT; Posted 13 May 2008
Posted to: Genetics, Immunology
Immunity to self co-generates regulatory T cells
Immune responses to self are kept in check by tolerance mechanisms, including suppression by regulatory T cells (Tregs). The defective generation of Tregs specific for self-antigens may lead to aut...
Received 08 April 2008 04:59 GMT; Posted 09 April 2008
Posted to: Immunology