http://precedings.nature.com/tags/Trichoplax Recently posted documents tagged with 'Trichoplax' Nature Publishing Group en Nature Precedings http://precedings.nature.com/images/header_logo.gif http://precedings.nature.com http://precedings.nature.com/documents/2170/version/1 Although, as their names imply, estrogen receptors [ERs] and estrogen-related receptors [ERRs] are related transcription factors, their evolutionary relationships to each other are not fully understood. To elucidate the origins and evolution of ERs and ERRs, we searched for their orthologs in the recently sequenced genome of Trichoplax, the simplest known animal, and in the genomes of three lophotrochozoans: Capitella, an annelid worm, Helobdella robusta, a leech, and Lottia gigantea, a snail. BLAST searches found an ERR in Trichoplax, but no ER. BLAST searches also found ERRs in all three lophotrochozoans and invertebrate-like ERs in Capitella and Lottia, but not in Helobdella. Unexpectedly we find that the Capitella ER sequence is closest to ERβ, unlike the other invertebrate ER sequences, which are closest to ERα. Our database searches and phylogenetic analysis indicate that invertebrate ERs evolved in a lophotrochozoan and steroid-binding ERs evolved in a deuterostome. http://precedings.nature.com/documents/2170/version/1 Wed, 13 Aug 2008 09:09:40 UTC Trichoplax, the simplest known animal, contains an estrogen-related receptor but no estrogen receptor: Implications for estrogen receptor evolution hdl:10101/npre.2008.2170.1 2008-08-13 Michael E. Baker Nature Precedings 2008-08-13T09:09:40Z Manuscript Developmental Biology Ecology Evolutionary Biology http://creativecommons.org/licenses/by/3.0/ http://precedings.nature.com/documents/1863/version/1 Although, as their names imply, vertebrate and invertebrate estrogen receptors [ERs] and estrogen-related receptors [ERRs] are related transcription factors, their evolutionary relationships to each other are not fully understood. We searched recently sequenced genome of Trichoplax, the simplest known animal, and genomes from three lophotrochozoans: Capitella, a worm, Helobdella robusta, a leech, and Lottia gigantea, a snail, to elucidate the origins and evolution of ERs and ERRs. BLAST found an ERR in Trichoplax, but no ER. BLAST searches of the lophotrochozaons found ERRs in all three and invertebrate ERs in Capitella and Lottia, but not in Helobdella. These database searches and a phylogenetic analyses indicate that invertebrate ERs arose in a protostome, and vertebrate ERs arose later in deuterostome. http://precedings.nature.com/documents/1863/version/1 Tue, 06 May 2008 22:32:29 UTC Trichoplax, the simplest known animal, contains an estrogen-related receptor: Implications for the evolution of vertebrate and invertebrate estrogen receptors hdl:10101/npre.2008.1863.1 2008-05-06 Michael E. Baker Nature Precedings 2008-05-06T22:32:29Z Manuscript Developmental Biology Ecology Evolutionary Biology http://creativecommons.org/licenses/by/3.0/