Submissions tagged with SNP
(7 documents)
Variation in PNPLA3 is associated with outcomes in alcoholic liver disease
Two recent genome-wide association studies have described associations of SNP variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels in population based cohorts. We inves…
Received 05 October 2009 19:14 UTC; Posted 06 October 2009
Posted to: Genetics & Genomics
SNP analysis reveals an evolutionary acceleration of the human-specific microRNAs
MicroRNAs are one class of important gene regulators at the post-transcriptional level by binding to the 3’UTRs of target mRNAs. It has been reported that human microRNAs are evolutionary conserved…
Received 29 July 2008 08:29 UTC; Posted 29 July 2008
Posted to: Genetics & Genomics, Bioinformatics, Evolutionary Biology
Gene and Pathway-Based Analysis: Second Wave of Genome-wide Association Studies
Despite great success of GWAS in identification of common genetic variants associated with complex diseases, the current GWAS have focused on single SNP analysis. However, single SNP analysis often…
Received 11 July 2008 00:52 UTC; Posted 14 July 2008
Posted to: Genetics & Genomics, Bioinformatics
Polymorphisms of the ENPP1 gene are not associated with type 2 diabetes or obesity in the Chinese Han population
Objective: Type 2 Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia and with a major feature of insulin resistance. Genetic association studies have suggested that …
Received 31 March 2008 05:58 UTC; Posted 01 April 2008
Posted to: Genetics & Genomics
Sensitivity Analysis of Self-Identified Race and Ethnicity (SIRE): Screening for Single Nucleotide Polymorphisms.
Within the realm of medical care, Self-Identified Race and Ethnicity (SIRE) categories are promoted as an inexpensive tool to identify underlying genotypic diversity. Scientific opinion is divided …
Received 17 January 2008 15:23 UTC; Posted 17 January 2008
Posted to: Genetics & Genomics
Biological networks and epistasis in genome-wide association studies
Over the last few years, technological improvements have made possible the genotyping of hundreds of thousands of SNPs, enabling whole-genome association studies. The first genome-wide association …
Received 16 July 2007 12:12 UTC; Posted 16 July 2007
Posted to: Genetics & Genomics, Bioinformatics
A periodic pattern of SNPs in the human genome
By surveying all validated SNPs in the human genome we have found that SNPs positioned 1, 2, 4, 6 or 8 bp apart are more frequent than SNPs 3, 5, 7 or 9 bp apart. This holds even when we correct fo…
Received 12 July 2007 07:49 UTC; Posted 13 July 2007
Posted to: Genetics & Genomics
