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      <title>Searching the World-Wide-Web using nucleotide and peptide sequences</title>
      <link>http://precedings.nature.com/documents/2492/version/1</link>
      <description>Background: No approaches have yet been developed to allow instant searching of the World-Wide-Web by just entering a string of sequence data. Though general search engines can be tuned to accept &#8216;processed&#8217; queries, the burden of preparing such &#8216;search strings&#8217; simply defeats the purpose of quickly locating highly relevant information. Unlike &#8216;sequence similarity&#8217; searches that employ dedicated algorithms (like BLAST) to compare an input sequence from defined databases, a direct &#8216;sequence based&#8217; search simply locates quick and relevant information about a blunt piece of nucleotide or peptide sequence. This approach is particularly invaluable to all biomedical researchers who would often like to enter a sequence and quickly locate any pertinent information before proceeding to carry out detailed sequence alignment. Results: Here, we describe the  theory and implementation of a web-based front-end for a search engine, like Google, which accepts sequence fragments and interactively retrieves a collection of highly relevant links and documents, in real-time. e.g. flat files like patent records, privately hosted sequence documents and regular databases.  Conclusions: The importance of this simple yet highly relevant tool will be evident when with a little bit of tweaking, the tool can be engineered to carry out searches on all kinds of hosted documents in the World-Wide-Web.Availability: Instaseq is free web based service that can be accessed by visiting the following hyperlink on the WWWhttp://instaseq.georgetown.edu  </description>
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      <pubDate>Tue, 11 Nov 2008 20:14:41 UTC</pubDate>
      <dc:title>Searching the World-Wide-Web using nucleotide and peptide sequences</dc:title>
      <dc:identifier>hdl:10101/npre.2008.2492.1</dc:identifier>
      <dc:date>2008-11-11</dc:date>
      <dc:creator>Natarajan Ganesan</dc:creator>
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