Submissions tagged with Drosophila
(11 documents)
Virtual Fly Brain: An ontology-linked schema of the Drosophila Brain
Drosophila neuro-anatomical data is scattered across a large, diverse literature dating back over 75 years and a growing number of community databases. Lack of a standardized nomenclature for neuro…
Received 17 November 2009 10:39 UTC; Posted 17 November 2009
Posted to: Neuroscience, Bioinformatics
Gender differences in a Drosophila transcriptomic model of chronic pentylenetetrazole induced behavioral deficit
A male Drosophila model of locomotor deficit induced by chronic pentylenetetrazole (PTZ), a proconvulsant used to model epileptogenesis in rodents, has recently been described. Antiepileptic drugs …
Received 25 July 2009 08:04 UTC; Posted 27 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
A Drosophila systems model of withdrawal from chronic pentylenetetrazole relevant in post-epileptogenesis
Rodent kindling induced by pentylenetetrazole (PTZ) is an established model of epileptogenesis and antiepileptic drug (AED) testing. Recently, a Drosophila systems model has been described in which…
Received 21 July 2009 16:19 UTC; Posted 21 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
A novel Drosophila transcriptomic and behavioral model detects potassium chloride with therapeutic potential
In a newly described Drosophila model, two of the five antiepileptic drugs (AEDs) tested, sodium valproate (NaVP) and levetiracetam (LEV), not ethosuximide (ETH), gabapentin (GBP) and vigabatrin …
Received 14 July 2009 15:23 UTC; Posted 17 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
A novel Drosophila post-genomic CNS drug discovery model detects tetraethylammonium chloride with therapeutic potential
A Drosophila behavioral and transcriptomic model of locomotor plasticity induced by chronic pentylenetetrazole (PTZ) has recently been developed. In this model, two of the five antiepileptic drug…
Received 10 July 2009 11:55 UTC; Posted 10 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
Transcriptomic analysis implicates ribosomal and energy metabolic pathways in antiepileptic drug action in a Drosophila model
Mechanisms of long term action of antiepileptic drugs (AEDs), used in treating epilepsy and many other neurological and psychiatric disorders, are poorly understood. Recently, a novel Drosophila tr…
Received 03 July 2009 14:57 UTC; Posted 07 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
mRNA diffusion explains protein gradients in Drosophila early development
We propose a new model describing the production and the establishment of the stable gradient of the Bicoid protein along the antero-posterior axis of the embryo of Drosophila. In this model, we …
Received 06 July 2009 14:12 UTC; Posted 06 July 2009
Posted to: Developmental Biology, Bioinformatics
The neurobiology of spontaneous actions and operant learning in Drosophila
Learning about the consequences of our actions (operant learning) is one of the major ways in which we learn to understand the world we live in. Despite our recent advances in the neurobiology of l…
Received 05 March 2009 14:56 UTC; Posted 06 March 2009
Posted to: Neuroscience
Mushroom-bodies regulate habit formation in Drosophila
Our past experience is one of the primary sources of information when faced with a choice. We ask ourselves: “what will happen if I do this?” Accurately predicting the consequences of our actions …
Received 17 September 2008 12:12 UTC; Posted 17 September 2008
Posted to: Genetics & Genomics, Neuroscience
Atmospheric hypoxia limits selection for large body size in insects
Recent geological models indicate a marked increase in atmospheric oxygen partial pressure (aPO2) to 32 kPa in the Permo-Carboniferous (approx. 300 million years ago), subsequently falling to 13 …
Received 24 April 2008 21:18 UTC; Posted 25 April 2008
Posted to: Ecology, Evolutionary Biology
