Pharmacology
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Differential Gene Expression of Human Mast cell Activation Reveals Gene profiles of Innate and Adaptive Immunity.
High-density oligonucleotide microarray is a promising approach for high throughput analysis. It has been extensively used in many areas of biomedical research. Immunoglobulin E (IgE) mediated alle…
Received 27 September 2007 14:37 UTC; Posted 28 September 2007
Posted to: Immunology, Molecular Cell Biology, Pharmacology, Bioinformatics
siRNA knockdown of SPHK1 in vivo protects mice from systemic, type-I Allergy.
Systemic anaphylaxis is considered to be a typical immediate hypersensitivity response, determined by the activation of immune cells,via antigen-induced aggregation of IgE-sensitized FcεRI cells….
Received 27 September 2007 14:31 UTC; Posted 27 September 2007
Posted to: Immunology, Molecular Cell Biology, Pharmacology
Diagnostic robustness of DNA microarrays in the classification of acute leukemia
Countless statistical methods have been described for the analysis of DNA microarrays, and each yields distinct results. This raises the question whether DNA microarrays are robust diagnostic tools…
Received 20 September 2007 15:34 UTC; Posted 26 September 2007
Posted to: Biotechnology, Cancer, Genetics & Genomics, Molecular Cell Biology, Pharmacology, Bioinformatics
DNA expression microarrays may be the wrong tool to identify biological pathways
DNA microarray expression signatures are expected to provide new insights into patho- physiological pathways. Numerous variant statistical methods have been described for each step of the signal an…
Received 18 September 2007 13:09 UTC; Posted 19 September 2007
Posted to: Biotechnology, Genetics & Genomics, Molecular Cell Biology, Pharmacology, Bioinformatics
Analysis of circadian pattern reveals tissue-specific alternative transcription in leptin signaling pathway
BackgroundIt has been previously reported that most mammalian genes display a circadian oscillation in their baseline expression. Consequently, the phase and amplitude of each component of a si…
Received 29 August 2007 18:50 UTC; Posted 30 August 2007
Posted to: Molecular Cell Biology, Pharmacology, Bioinformatics
Opposite effects of two zinc(II) dithiocarbamates on NF-kB pathway
Inhibiting nuclear factor-kappaB (NF-kB) activation in anticancer and antiinflammatory therapy is of topical interest. Current research in molecular biology has dramatically advanced in the underst…
Received 15 August 2007 11:21 UTC; Posted 16 August 2007
Posted to: Cancer, Chemistry, Molecular Cell Biology, Pharmacology
High-Value Phytochemicals from Grape Cane Waste: Potential Value-Added Viticultural Sources of Trans-Resveratrol and Trans-e-Viniferin with Medicinal and Anti-Phytopathogenic Applications
Grape canes as agricultural waste from commercial viticultural activities represent a potentially important source of the well-known medicinal and anti-phytopathogenic stilbene compounds trans-resv…
Received 07 August 2007 01:49 UTC; Posted 07 August 2007
Posted to: Biotechnology, Chemistry, Pharmacology, Earth & Environment
Biological Activities of Extracts from Sumac (Rhus spp.): A Review
Sumac is the common name for a genus (Rhus) that contains over 250 individual species of flowering plants in the family Anacardiaceae. These plants are found in temperate and tropical regions world…
Received 06 August 2007 22:12 UTC; Posted 07 August 2007
Posted to: Chemistry, Pharmacology, Plant Biology
Allosteric modulation of beta1 integrin function induces lung repair in animal model of emphysema.
Emphysema is a progressive lung disease characterised by loss of lung parenchyma with associated functional changes including decreased tissue elastance. Here we report beta1 integrin is a novel ta…
Received 12 July 2007 10:54 UTC; Posted 13 July 2007
Posted to: Pharmacology
The nitrite anion: the key intermediate in alkyl nitrates degradative mechanism.
Alkyl nitrates, in vivo, are metabolized to yield nitric oxide, and thiol groups are considered necessary cofactors. This statement is based on studies that underline how these species potentiate…
Received 26 June 2007 07:50 UTC; Posted 26 June 2007
Posted to: Chemistry, Pharmacology
