Pharmacology
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Establishing a multicellular model by three-dimensional cell-assembly technique for metabolic syndrome
One of the major obstacles in developing multifunctional drugs for the metabolic syndrome (MS) is lack of in vitro models that capture more complex features of the disease. Here we give the first r…
Received 08 January 2008 00:55 UTC; Posted 08 January 2008
Posted to: Biotechnology, Pharmacology
COX inhibition: Catalepsy and Striatum Dopaminergic-GABAergic-Glutamatergic Neurotransmission
Selective COX-2 and COX-1 inhibitors were administered (i.p. acutely) to normal and parkinsonian rats, followed by the analysis of the striatal dopamine, GABA and glutamate concentrations using the…
Received 01 January 2008 18:05 UTC; Posted 09 January 2008
Posted to: Neuroscience, Pharmacology
Are plants with anti-cancer activity resistant to crown gall? : A test of hypothesis
The Crown gall tumour assay (CGTA) is one of several bench top bioassays recommended for the rapid screening of plants with anti-cancer activity. The rationale for the use of the bioassay is that t…
Received 22 December 2007 10:30 UTC; Posted 28 December 2007
Posted to: Cancer, Pharmacology, Plant Biology
Application of the Sensory Contact Model for Pharmacological Studies under Simulated Clinical Conditions
The sensory contact model allows forming different psycho-pathological states (anxious depression, catalepsy, social withdrawal, pathological aggression, cognition disturbances, anhedonia, addictiv…
Received 19 December 2007 07:27 UTC; Posted 19 December 2007
Posted to: Neuroscience, Pharmacology
The concentration of homocysteine-derived disulfides in human coronary artery
Background Based on previous findings, we have estimated that, in injured coronary artery tissue, the low molecular weight disulfides homocystine and cysteine-homocysteine, otherwise identified…
Received 18 December 2007 06:55 UTC; Posted 18 December 2007
Posted to: Chemistry, Pharmacology
Prehistoric psychotropic consumption in Andean Chilean mummies
Hallucinogenic plants are often regarded as the main source of psychoactive drugs in antiquity to reach deep altered states of consciousness1,2. Many researchers believe this was particularly tru…
Received 29 November 2007 00:18 UTC; Posted 03 December 2007
Posted to: Chemistry, Pharmacology
Side effect profile prediction – Tackling Big Pharma’s worst nightmare at an early stage
This talk presents a method that predicts adverse side effects for molecules based on the chemical structure only. Also, targets for the compounds are predicted. Therefore it becomes possible to li…
Received 18 October 2007 21:10 UTC; Posted 23 October 2007
Posted to: Chemistry, Pharmacology, Bioinformatics
Tumor necrosis factor and caspase in response to soluble or microparticle-incorporated drugs in Mycobacterium tuberculosis infection
We compared the effects of microparticles (MP) containig anti-tubercular drugs and those of the drugs themselves on the host macrophage (MΦ) response to infection with Mycobacterium tuberculosis H3…
Received 28 September 2007 17:12 UTC; Posted 30 September 2007
Posted to: Immunology, Pharmacology
Current status of herbal and their future perspectives
Traditional medicine is the synthesis of therapeutic experience of generations of practicing physicians of indigenous systems of medicine. Throughout the history of mankind, many infectious disease…
Received 28 September 2007 08:14 UTC; Posted 28 September 2007
Posted to: Pharmacology, Plant Biology
Genome activity profiling of monomeric-IgE and Fc-epsilon-RI-aggregation on human mast cells reveals a complex network of genes involved in inflammatory responses.
Mast cell activation, mediates type-1 allergic responses, one of the most powerful reactions of the immune system. However, mast cells activation is becoming increasingly linked to inflammatory, au…
Received 27 September 2007 14:50 UTC; Posted 28 September 2007
Posted to: Immunology, Molecular Cell Biology, Pharmacology, Bioinformatics
