Pharmacology
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Steroid substrate-induced epimerase mechanism in the active site of the human 11β-hydroxysteroid dehydrogenase type 1
Cytochrome P4507B1 7α-hydroxylates dehydroepiandrosterone (DHEA), epiandrosterone (EpiA) and 5α-androstane-3β,17β-diol (Adiol). 11β-Hydroxysteroid dehydrogenase type 1 (1…
Received 06 May 2008 16:23 UTC; Posted 06 May 2008
Posted to: Chemistry, Pharmacology
Systems Pharmacology
The slides are from a presentation given by Professor Ravi Iyengar from Mount Sinai School of Medicine at the Drug Forum Meeting #9 that took place in Washington, DC on February 20-21, 2008. The sl…
Received 01 April 2008 16:19 UTC; Posted 02 April 2008
Posted to: Biotechnology, Chemistry, Pharmacology, Bioinformatics
Systemic similarity analysis of compatibility drug-induced multiple pathway patterns in vivo
A major challenge in post-genomic research is to understand how physiological and pathological phenotypes arise from the networks of expressed genes and to develop powerful tools for translating th…
Received 15 March 2008 08:15 UTC; Posted 17 March 2008
Posted to: Neuroscience, Pharmacology
Phytochemical Approach and Bioanalytical Strategy to Develop Chaperone-Based Medications
Currently, no pharmaceuticals for the etiological treatment of degenerative protein-misfolding diseases (e.g., ALS, Alzheimer’s or prion diseases) are commercially available. Therefore, in this tec…
Received 08 April 2008 16:45 UTC; Posted 09 April 2008
Posted to: Chemistry, Pharmacology, Plant Biology
Apoptotic gene expression in neuropathic pain
Pain initiated or caused by a primary lesion or dysfunction in the nervous system is defined as neuropathic pain. It results from direct injury to nerves in the peripheral or central nervous system…
Received 30 January 2008 15:13 UTC; Posted 30 January 2008
Posted to: Pharmacology
Role and immunomodulatory profile of histamine receptors by H1 and H2 antagonists
The present study was designed to delineate the immunomodulatory role of histamine receptors (H1- and H2-) on induction of antibody response to sheep red blood cells (SRBC), as well as the antibody…
Received 29 January 2008 10:31 UTC; Posted 29 January 2008
Posted to: Immunology, Microbiology, Pharmacology
Formulation and in vitro Evaluation of Eudragit L100 piroxicam
The aim of this study was to formulate and evaluate controlled release preparations of a water-insoluble drug using Copolymers synthesized from acrylic and methacrylic acidesters (Eudragit L 100)...
Received 27 January 2008 20:33 UTC; Posted 28 January 2008
Posted to: Chemistry, Pharmacology
The spread of antimalarial drug resistance: A mathematical model with practical implications for ACT drug policies
Most malaria-endemic countries are implementing a change in antimalarial drug policy to artemisinin combination therapy (ACT). The impact of different drug choices and implementation strategies is …
Received 24 January 2008 05:15 UTC; Posted 24 January 2008
Posted to: Microbiology, Pharmacology, Bioinformatics
In Silico Docking Analysis of Peptide Deformylase (PDF) – A Novel Target for Prophylaxis of Leptospirosis
Peptide deformylase (PDF) is a metalloproteinase and executes an essential step in the maturation of proteins in eubacteria, by removing the formyl group from the N-terminal methionine residue of r…
Received 16 January 2008 06:21 UTC; Posted 21 January 2008
Posted to: Microbiology, Pharmacology, Bioinformatics
New source for L-iditol and taxanes
We describe the first report of the recovery of L-iditol and Taxane from an angiosperm- Yunnanopilia longistaminata (W.Z.Li) C.Y.Wu et D.Z.Li (Opiliaceae). Two taxane compounds and L-iditol were is…
Received 09 January 2008 06:06 UTC; Posted 14 January 2008
Posted to: Chemistry, Pharmacology, Plant Biology
