Pharmacology
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Low Protein Diet Consumption Antagonize the Age-associated Change in Hypothalamic GABA Receptor activity
Amounts of dietary protein as well as the duration of its supplementation are criticalfactors that correlate with the hypothalamic GABAergic activity and immune functionduring aging. Here we ev…
Received 10 September 2008 22:03 UTC; Posted 11 September 2008
Posted to: Neuroscience, Pharmacology
Validated, Ultra Violet Spectroscopy method for the Dissolution study of Mycophenolate mofetil immediate release 500mg tablets
A simple, selective and precise dissolution method was developed and validated for the Mycophenolate mofetil immediate release tablets. The method employed dissolution medium 0.1N HCl (pH1.2) and v…
Received 01 September 2008 11:20 UTC; Posted 03 September 2008
Posted to: Chemistry, Pharmacology
Optimization of the Ugi reaction using parallel synthesis and automated liquid handling
The Ugi reaction has proved to be a convenient way to quickly create diverse libraries of compounds. It involves the reaction of an amine, an aldehyde, a carboxylic acid and an isonitrile typically…
Received 27 August 2008 20:56 UTC; Posted 29 August 2008
Posted to: Chemistry, Pharmacology
Successful use of axonal transport for drug delivery by synthetic molecular vehicles
We report the use of axonal transport to achieve intraneural drug delivery. We constructed a novel tripartite complex of an axonal transport facilitator conjugated to a linker molecule bearing up t…
Received 06 August 2008 15:14 UTC; Posted 07 August 2008
Posted to: Biotechnology, Chemistry, Molecular Cell Biology, Neuroscience, Pharmacology
Intra-mammary single infusion of casein hydrolyzate in dairy cows as alternative dry period treatment: Curing bacterial infection and increasing milk yield in the subsequent lactations
Conclusions: This study sustain previous results that treatment with CNH is a powerful mean to eradicated bacterial infection, and strongly highlight the potential of this method to serve as a viab…
Received 31 July 2008 09:27 UTC; Posted 01 August 2008
Posted to: Biotechnology, Microbiology, Pharmacology
The Mass-Action-Law Based GPS Concept for Bio-Informatics
The unified theory of dose and effect, as indicated by the median-effect equation for single and multiple entities and for the first and higher order kinetic/dynamic, has been established by T.C. C…
Received 18 July 2008 15:47 UTC; Posted 22 July 2008
Posted to: Biotechnology, Pharmacology, Bioinformatics
Effects of Cations and PH on Antimicrobial Activity of Thanatin and s-Thanatin against Escherichia coli ATCC25922 and B. subtilis ATCC 21332
Thanatin and s-thanatin were insect antimicrobial peptides which have shown potent antimicrobial activities on a variety of microbes. In order to investigate the effect of cations and pH on the act…
Received 25 June 2008 07:10 UTC; Posted 25 June 2008
Posted to: Microbiology, Pharmacology
The Broad Spectrum HDAC Inhibitor PCI-24781 Induces Caspase- and ROS-Dependent Apoptosis and is Synergistic with Bortezomib in Lymphoma
We investigated the cytotoxicity and biology of the novel broad-spectrum hydroxamic acid-based histone deacetylase inhibitor (HDACi), PCI-24781. PCI-24781 was studied alone and combined with bortez…
Received 23 June 2008 15:46 UTC; Posted 12 July 2008
Posted to: Cancer, Pharmacology
Effect of Baicalin on inflammatory mediator levels and microcirculation disturbance in rats with severe acute pancreatitis
Objective: To investigate the effect of Bacailin on inflammatory mediator levels and microcirculation disturbance in severe acute pancreatitis (SAP) rats and explore its therapeutic mechanism on th…
Received 12 June 2008 11:57 UTC; Posted 16 June 2008
Posted to: Pharmacology
Desynchronization of pathological low-frequency brain activity by the hypnotic drug zolpidem.
Reports of the beneficial effects of the hypnotic imidazopyridine, zolpidem, described in persistent vegetative state1, 2 have been replicated recently in brain-injured and cognitively impaired p…
Received 11 June 2008 15:35 UTC; Posted 11 June 2008
Posted to: Neuroscience, Pharmacology
