Pharmacology
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Three Dimensional Quantitative Structure-Activity Relationships of Sulfonamides Binding Monoclonal Antibody by Comparative Molecular Field Analysis
The three-dimensional quantitative structure-activity relationship (3D-QSAR) model of sulfonamide analogs binding a monoclonal antibody (MabSMR) produced against sulfamerazine, was carried out by c…
Received 12 December 2008 02:36 UTC; Posted 12 December 2008
Posted to: Biotechnology, Chemistry, Pharmacology
Surface Modified Ultrathin Polyelectrolyte Nanoreservoir for Delivery of Proteins: Evaluation in Terms of Controlled Release and Biocompatibility
The proposed ultrathin polyelectrolyte nanoreservoir (UPN) was fabricated in two combinations by alternate layering of polyelectrolytes poly (allylamine hydrochloride) along with sodium poly (styre…
Received 21 November 2008 09:05 UTC; Posted 21 November 2008
Posted to: Pharmacology
Open Source Drug Discovery
Tuberculosis is a ravaging disease killing one person in every 1.5 minutes in India alone. Someone in the world is newly infected with TB bacilli every second. Overall, one-third of the world’s pop…
Received 19 November 2008 07:29 UTC; Posted 01 December 2008
Posted to: Pharmacology, Bioinformatics
Genome-wide transcription analysis of interaction between the human macrophage and Mycobacterium tuberculosis during concurrent drug administration by conventional and novel methods
Targeted drug delivery to alveolar macrophages harboring Mycobacterium tuberculosis (Mtb) holds promise of high efficacy against pulmonary tuberculosis (TB). It was investigated whether inhalable m…
Received 31 October 2008 05:43 UTC; Posted 04 November 2008
Posted to: Pharmacology
PLA Microparticles for Pulmonary Delivery of AntiTB drugs: Biodistribution study
A dry powder inhalable (DPI) microparticles comprising anti-tuberculosis drugs incorporated in biodegradable polymers was developed for the treatment of pulmonary tuberculosis (P. Muttil et al. 2…
Received 29 October 2008 05:46 UTC; Posted 29 October 2008
Posted to: Pharmacology
Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11β-hydroxysteroid dehydrogenase 1
Intracellular glucocorticoid reactivation is catalyzed by 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), which functions predominantly as a reductase in cells expressing hexose-6-phosphat…
Received 22 October 2008 18:32 UTC; Posted 22 October 2008
Posted to: Molecular Cell Biology, Pharmacology, Bioinformatics
Predictive Models of Insulin Resistance Derived from Simple Morphometric and Metabolic Measurements Related to Obesity in Baboons.
Non-human primates are valuable models for the study of insulin resistance and human obesity. In baboons, insulin sensitivity levels can be evaluated directly with the euglycemic clamp and is highl…
Received 22 October 2008 14:53 UTC; Posted 24 October 2008
Posted to: Pharmacology
Steroidal anti inflammatory drug betamethasone significantly alters level of striatal dopamine in a rat model of Parkinson’s disease
Many scientific efforts have been well done to investigate the effects of anti inflammatory agents on the degenerative brain diseases such as Parkinson’s (PD) or Alzheimer’s disease and their affil…
Received 25 September 2008 20:10 UTC; Posted 26 September 2008
Posted to: Chemistry, Immunology, Neuroscience, Pharmacology
Chronic cocaine enhances release of neuroprotective amino acid taurine: a microdialysis study
Cocaine inhibits high-affinity neurotransmitter uptake at the presynaptic nerve terminals to increase synaptic levels of dopamine, norepinephrine and serotonin1. This increase of synaptic dopamin…
Received 22 September 2008 19:49 UTC; Posted 24 September 2008
Posted to: Neuroscience, Pharmacology
Dibutyltin Disrupts Glucocorticoid Receptor Function and Impairs Glucocorticoid-induced Suppression of Cytokine Production
Background. Organotins are highly toxic and widely distributed environmental chemicals. Dibutyltin (DBT) is used as stabilizer in the production of polyvinyl chloride plastics, and it is also the…
Received 18 September 2008 19:55 UTC; Posted 19 September 2008
Posted to: Immunology, Pharmacology, Bioinformatics
