Pharmacology
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Functional presynaptic α6-containing nicotinic acetylcholine receptors participate in nicotine reward in the VTA: where and how
In the ventral tegmental area (VTA), α6-nAChRs express abundantly, but their location, function, pharmacology, and roles in cholinergic modulation of dopaminergic (DA) neurons remain elusive….
Received 17 February 2009 03:26 UTC; Posted 20 February 2009
Posted to: Neuroscience, Pharmacology
Effect of Stimulators upon Human Hepatic Adenylate Cyclase Activity: A Tool of Nitroimidazole Cytotoxicity Assessment
Nitroimidazole is an antibiotic and radiosensitizer chemical with great potentials in imaging. The hepato-cytoxicity evaluation of nitroimidazole and possible energy status changes in liver cells d…
Received 05 February 2009 23:21 UTC; Posted 09 February 2009
Posted to: Molecular Cell Biology, Pharmacology
Paclitaxel delivery by micro/nano encapsulation using layer-by-layer assembly
A novel formulation of paclitaxel (PTX) has been developed by providing multilayer assembly over drug loaded porous CaCO3 microparticles (CaCO3 MP) using combination of biocompatible and biodegrada…
Received 21 January 2009 11:51 UTC; Posted 22 January 2009
Posted to: Pharmacology
Neuronal plasticity: cell-based strategy for target identification and validation
While growing neurites are relatively plastic during development, their plasticity levels drop rapidly as neurons mature and become integrated into neuronal networks. As a consequence, the central …
Received 13 January 2009 02:16 UTC; Posted 13 January 2009
Posted to: Molecular Cell Biology, Neuroscience, Pharmacology
Frizzled Proteins are bona fide G Protein-Coupled Receptors
Receptors of the Frizzled family initiate Wnt ligand-dependent signaling controllingmultiple steps in organism development and highly conserved in evolution.Misactivation of the Wnt/Frizzled si…
Received 08 January 2009 16:38 UTC; Posted 09 January 2009
Posted to: Cancer, Developmental Biology, Molecular Cell Biology, Pharmacology
Limiting effect of diazepam on Lewis lung carcinoma metastasis in anxious male mice
Aim: It has been shown previously that chronic social defeat stress produces development of strong anxiety and increases intensity of experimental metastasis in the losers in comparison with the …
Received 03 January 2009 06:13 UTC; Posted 05 January 2009
Posted to: Cancer, Neuroscience, Pharmacology
The Hepatocellular Hypoxia Criteria:2’Nitroimidazole Effect on Hepatocyte Carbohydrate Metabolizing Enzymes
Aim: to understand the 2’-nitroimidazole induced hypoxia and liver cell interaction, we proposed a “Hapatocellular Hypoxia Criteria”. Hypothesis: The nitroimidazole induced metabolic energy loss a…
Received 30 December 2008 21:07 UTC; Posted 30 December 2008
Posted to: Biotechnology, Cancer, Pharmacology
Expression of Green Fluorescence Protein (GFP) in Zebrafish Muscle through Injection: A Gene Therapy Model
Expression of the target gene is important for gene therapy. Presently, localized transgenesis is used for gene therapy which can be achieved by a target gene expression. Here, we have reported the…
Received 25 December 2008 07:28 UTC; Posted 28 December 2008
Posted to: Biotechnology, Genetics & Genomics, Pharmacology
Capsaicin protects neuromuscular junctions from the inhibitory effects of botulinum neurotoxin A
Within 24 hrs after injecting botulinum neurotoxin A (BoNT/A) into the hindlimb, mice lost the toe spread reflex and developed progressive muscle weakness. At the same time, the compound muscle act…
Received 24 December 2008 22:08 UTC; Posted 27 December 2008
Posted to: Neuroscience, Pharmacology
Timing feedback-inhibition of the male reproductive hormone axis
Hormonal methods of male contraception have addressed feedback-inhbition of the cascade of hormones that has evolved to regulate sperm production but high concentrations of testosterone (T) in the …
Received 12 December 2008 10:27 UTC; Posted 18 December 2008
Posted to: Neuroscience, Pharmacology
