Pharmacology
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Development and Characterization of Eudragit RS 100 Loaded Microsponges and its Colonic Delivery Using Natural Polysaccharides
In the present work, paracetamol loaded eudragit based microsponges were prepared using quasi-emulsion solvent diffusion method. The compatibility of the drug with various formulation components wa…
Received 22 August 2009 12:42 UTC; Posted 24 August 2009
Posted to: Chemistry, Pharmacology
A Study of the Mechanism of Action of Zervamicin IIB Peptide Antibiotic by Molecular Dynamics Simulation
We model mechanism of action of a channel-forming peptide antibiotic, zervamicin IIB, by molecular dynamics (MD) simulation. Interaction of this peptide with neutral and negatively charged lipid bi…
Received 16 August 2009 20:29 UTC; Posted 17 August 2009
Posted to: Pharmacology, Bioinformatics
Gender differences in a Drosophila transcriptomic model of chronic pentylenetetrazole induced behavioral deficit
A male Drosophila model of locomotor deficit induced by chronic pentylenetetrazole (PTZ), a proconvulsant used to model epileptogenesis in rodents, has recently been described. Antiepileptic drugs …
Received 25 July 2009 08:04 UTC; Posted 27 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
A Drosophila systems model of withdrawal from chronic pentylenetetrazole relevant in post-epileptogenesis
Rodent kindling induced by pentylenetetrazole (PTZ) is an established model of epileptogenesis and antiepileptic drug (AED) testing. Recently, a Drosophila systems model has been described in which…
Received 21 July 2009 16:19 UTC; Posted 21 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
A novel Drosophila transcriptomic and behavioral model detects potassium chloride with therapeutic potential
In a newly described Drosophila model, two of the five antiepileptic drugs (AEDs) tested, sodium valproate (NaVP) and levetiracetam (LEV), not ethosuximide (ETH), gabapentin (GBP) and vigabatrin …
Received 14 July 2009 15:23 UTC; Posted 17 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
Rescue with an anti-inflammatory peptide of chickens infected H5N1 avian flu
Chickens suffering from avian flu caused by H5N1 influenza virus are destined to die within 2 days due to a systemic inflammatory response. Since HVJ infection (1,2) and influenza virus infection (...
Received 14 July 2009 11:43 UTC; Posted 17 July 2009
Posted to: Immunology, Microbiology, Pharmacology
A novel Drosophila post-genomic CNS drug discovery model detects tetraethylammonium chloride with therapeutic potential
A Drosophila behavioral and transcriptomic model of locomotor plasticity induced by chronic pentylenetetrazole (PTZ) has recently been developed. In this model, two of the five antiepileptic drug…
Received 10 July 2009 11:55 UTC; Posted 10 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
Transcriptomic analysis implicates ribosomal and energy metabolic pathways in antiepileptic drug action in a Drosophila model
Mechanisms of long term action of antiepileptic drugs (AEDs), used in treating epilepsy and many other neurological and psychiatric disorders, are poorly understood. Recently, a novel Drosophila tr…
Received 03 July 2009 14:57 UTC; Posted 07 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
Chromobacterium violaceum ATCC12472: Multi-drug and ethidium bromide resistant
Chromobacterium violaceum is an opportunistic human pathogen causing a range of gastric infections and occasionally septicemia. This Gram-negative bacillus is a common inhabitant of soil and wate…
Received 23 June 2009 08:10 UTC; Posted 23 June 2009
Posted to: Microbiology, Pharmacology
Polymorphisms of CYP1A1 I462V and GSTM1 genotypes and lung cancer susceptibility in Mongolian
Aim: To study the genotype of cytochrome P450 1A1(CYP1A1) I462V and glutathions S-transferase M1( GSTM1) and the relationship of the genetic polymorphism of them with the susceptibility of lung can…
Received 12 June 2009 00:40 UTC; Posted 18 June 2009
Posted to: Cancer, Pharmacology
