Pharmacology
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Molecular Static and Dynamic Analyses reveal Flaw in Murine Model used by US FDA to Detect Drug Carcinogenicity
The US FDA currently accepts carcinogenicity studies of pharmaceutical drugs based on murine models. In addition to 6 month studies with p53(+/-) and ras.H2 transgenic mice, lifetime studies (typic…
Received 15 June 2007 18:05 UTC; Posted 15 June 2007
Posted to: Biotechnology, Cancer, Immunology, Pharmacology, Bioinformatics
Dynamic Topology of Biological Networks
The mammalian cell can be represented as a large modular network that consists of a central signal network that interacts with and regulates multiple cellular machines that are responsible for phen…
Received 23 January 2007 16:48 UTC; Posted 23 January 2007
Posted to: Molecular Cell Biology, Neuroscience, Pharmacology, Bioinformatics
PharmGKB: Capturing knowledge to catalyze pharmacogenomics research
This is a powerpoint presentation made initially at the Cold Spring Harbor meeting on Pharmacogenomics, November 2006. It discusses the PharmGKB (http://www.pharmgkb.org/) and how we are building …
Received 30 November 2006 07:29 UTC; Posted 30 November 2006
Posted to: Biotechnology, Genetics & Genomics, Pharmacology
