Pharmacology
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Successful use of axonal transport for drug delivery by synthetic molecular vehicles
We report the use of axonal transport to achieve intraneural drug delivery. We constructed a novel tripartite complex of an axonal transport facilitator conjugated to a linker molecule bearing up t...
Received 06 August 2008 15:08 GMT; Posted 07 August 2008
Posted to: Biotechnology, Chemistry, Molecular Cell Biology, Neuroscience, Pharmacology
Intra-mammary single infusion of casein hydrolyzate in dairy cows as alternative dry period treatment: Curing bacterial infection and increasing milk yield in the subsequent lactations
Conclusions: This study sustain previous results that treatment with CNH is a powerful mean to eradicated bacterial infection, and strongly highlight the potential of this method to serve as a viab...
Received 29 July 2008 07:03 GMT; Posted 01 August 2008
Posted to: Biotechnology, Microbiology, Pharmacology
The Mass-Action-Law Based GPS Concept for Bio-Informatics
The unified theory of dose and effect, as indicated by the median-effect equation for single and multiple entities and for the first and higher order kinetic/dynamic, has been established by T.C. C...
Received 18 July 2008 15:36 GMT; Posted 22 July 2008
Posted to: Biotechnology, Pharmacology, Bioinformatics
The Broad Spectrum HDAC Inhibitor PCI-24781 Induces Caspase- and ROS-Dependent Apoptosis and is Synergistic with Bortezomib in Lymphoma
We investigated the cytotoxicity and biology of the novel broad-spectrum hydroxamic acid-based histone deacetylase inhibitor (HDACi), PCI-24781. PCI-24781 was studied alone and combined with bortez...
Received 21 June 2008 17:19 GMT; Posted 12 July 2008
Posted to: Cancer, Pharmacology
Effects of Cations and PH on Antimicrobial Activity of Thanatin and s-Thanatin against Escherichia coli ATCC25922 and B. subtilis ATCC 21332
Thanatin and s-thanatin were insect antimicrobial peptides which have shown potent antimicrobial activities on a variety of microbes. In order to investigate the effect of cations and pH on the act...
Received 25 June 2008 06:58 GMT; Posted 25 June 2008
Posted to: Microbiology, Pharmacology
Effect of Baicalin on inflammatory mediator levels and microcirculation disturbance in rats with severe acute pancreatitis
Objective: To investigate the effect of Bacailin on inflammatory mediator levels and microcirculation disturbance in severe acute pancreatitis (SAP) rats and explore its therapeutic mechanism on th...
Received 12 June 2008 11:33 GMT; Posted 16 June 2008
Posted to: Pharmacology
Desynchronization of pathological low-frequency brain activity by the hypnotic drug zolpidem.
Reports of the beneficial effects of the hypnotic imidazopyridine, zolpidem, described in persistent vegetative state1, 2 have been replicated recently in brain-injured and cognitively impaired pat...
Received 11 June 2008 15:27 GMT; Posted 11 June 2008
Posted to: Neuroscience, Pharmacology
Steroid substrate-induced epimerase mechanism in the active site of the human 11β-hydroxysteroid dehydrogenase type 1
Cytochrome P4507B1 7α-hydroxylates dehydroepiandrosterone (DHEA), epiandrosterone (EpiA) and 5α-androstane-3β,17β-diol (Adiol). 11β-Hydroxysteroid dehydrogenase type 1 (11&...
Received 06 May 2008 15:51 GMT; Posted 06 May 2008
Posted to: Chemistry, Pharmacology
Phytochemical Approach and Bioanalytical Strategy to Develop Chaperone-Based Medications
Currently, no pharmaceuticals for the etiological treatment of degenerative protein-misfolding diseases (e.g., ALS, Alzheimer’s or prion diseases) are commercially available. Therefore, in this tec...
Received 24 February 2008 21:10 GMT; Posted 09 April 2008
Posted to: Chemistry, Neuroscience, Pharmacology
Systems Pharmacology
The slides are from a presentation given by Professor Ravi Iyengar from Mount Sinai School of Medicine at the Drug Forum Meeting #9 that took place in Washington, DC on February 20-21, 2008. The sl...
Received 01 April 2008 16:12 GMT; Posted 02 April 2008
Posted to: Biotechnology, Chemistry, Pharmacology, Bioinformatics