Neuroscience
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A novel Drosophila post-genomic CNS drug discovery model detects tetraethylammonium chloride with therapeutic potential
A Drosophila behavioral and transcriptomic model of locomotor plasticity induced by chronic pentylenetetrazole (PTZ) has recently been developed. In this model, two of the five antiepileptic drug…
Received 10 July 2009 11:55 UTC; Posted 10 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
ECoG-based short-range recurrent stimulation techniques to stabilize tissue at risk of progressive damage: Theory based on clinical observations
We introduce theoretical concepts based on chaos control to stabilize in acute stroke the tissue at risk of progressive damage by preventing adverse effects of waves of mass neuronal depolarization…
Received 07 July 2009 16:13 UTC; Posted 08 July 2009
Posted to: Biotechnology, Neuroscience
Transcriptomic analysis implicates ribosomal and energy metabolic pathways in antiepileptic drug action in a Drosophila model
Mechanisms of long term action of antiepileptic drugs (AEDs), used in treating epilepsy and many other neurological and psychiatric disorders, are poorly understood. Recently, a novel Drosophila tr…
Received 03 July 2009 14:57 UTC; Posted 07 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
Evolutionary game theory and the evolution of neuron populations, ring rates, and decisionmaking
Ours, is the first application of dynamical evolutionary games to decision making in neuroscience. Firing neurons are the players. The strategy is their firing rate. Neurons with equal firing rates…
Received 25 June 2009 19:04 UTC; Posted 29 June 2009
Posted to: Neuroscience
Progression of Parkinson’s disease pathology is reproduced by intragastric administration of rotenone in mice
In Parkinson’s disease patients pathology follows a characteristic pattern involving inter alia the enteric nervous system, the dorsal motor nucleus of the vagus, the intermediolateral nucleus of t…
Received 22 June 2009 18:26 UTC; Posted 22 June 2009
Posted to: Neuroscience
Connectivity reflects coding: A model of voltage-based spike-timing-dependent-plasticity with homeostasis
Electrophysiological connectivity patterns in cortex often show a few strong connections in a sea of weak connections. In some brain areas a large fraction of strong connections are bidirectional, ...
Received 22 June 2009 09:12 UTC; Posted 22 June 2009
Posted to: Neuroscience
The Predominance of Electric Transport in Synaptic Transmission
The quantitative description of the motion of neurotransmitters in the synaptic cleft appears to be one of the most difficult problems in the modeling of synapses. Here we show in contradiction to …
Received 19 June 2009 10:04 UTC; Posted 22 June 2009
Posted to: Neuroscience
Averaging Transformations of Synaptic Potentials on Networks
The problem of the transformation of microscopic information to the macroscopic level is an intriguing challenge in computational neuroscience, but also of general mathematical importance. Here, a …
Received 19 June 2009 10:08 UTC; Posted 19 June 2009
Posted to: Neuroscience
Range-based techniques for discovering optimality and analyzing scaling relationships in neuromechanical systems
In this paper, a method for decoupling the neuromuscular function of a set of limbs from the role morphology plays in regulating the performance of an activity is introduced. This method is based o…
Received 16 June 2009 15:55 UTC; Posted 18 June 2009
Posted to: Neuroscience, Bioinformatics
Small critical RNAs in the scrapie agent
Unconventional infectious agents cause transmissible spongiform encephalopathy (TSE) diseases including scrapie and bovine spongiform encephalopathy (BSE) in animals and Creutzfeldt-Jakob disease i…
Received 16 June 2009 14:40 UTC; Posted 16 June 2009
Posted to: Microbiology, Neuroscience
