Molecular Cell Biology
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What are the ethical and social responsibilities of scientists?
Presented as part of the session titled “Sharing scientific data: who benefits?” at ESOF (The Euroscience Open Forum) 2008.Session abstract: Digital datasets—text-based, numeric, audio, video o…
Received 13 August 2008 14:43 UTC; Posted 19 August 2008
Posted to: Genetics & Genomics, Molecular Cell Biology, Bioinformatics
Stress responsive miR-23a attenuates skeletal muscle atrophy by targeting MAFbx /atrogin-1
Muscle atrophy occurs in many pathological states and results primarily from accelerated protein degradation by the ubiquitin-proteasome pathway. We used dexamethasone to induce muscle wasting and …
Received 13 August 2008 02:17 UTC; Posted 15 August 2008
Posted to: Developmental Biology, Molecular Cell Biology
Successful use of axonal transport for drug delivery by synthetic molecular vehicles
We report the use of axonal transport to achieve intraneural drug delivery. We constructed a novel tripartite complex of an axonal transport facilitator conjugated to a linker molecule bearing up t…
Received 06 August 2008 15:14 UTC; Posted 07 August 2008
Posted to: Biotechnology, Chemistry, Molecular Cell Biology, Neuroscience, Pharmacology
A Targeted Therapeutic Rescues Botulinum Toxin-A Poisoned Neurons
Botulinum neurotoxin (BoNT), a Category A biothreat agent, is the most potent poison known to mankind. Currently no antidote is available to rescue poisoned synapses. BoNT acts specifically by bloc…
Received 01 August 2008 17:21 UTC; Posted 13 August 2008
Posted to: Biotechnology, Molecular Cell Biology, Neuroscience
Smoking-induced long-lasting modifications of human platelet serotonin catabolism through a MAO epigenetic regulation
Postulating that serotonin, secreted from smoking-activated platelets, could be involved in smoking-induced vascular modifications, we studied 115 men distributed in smokers (S), former smokers (FS…
Received 23 July 2008 14:00 UTC; Posted 28 July 2008
Posted to: Molecular Cell Biology
A coordinated phosphorylation cascade initiated by MSK1 directs RAR alpha recruitment to target gene promoters
The nuclear retinoic acid (RA) receptor alpha (RARα) is a transcriptional transregulator that controls the expression of specific gene subsets through binding at response elements and dynami…
Received 22 July 2008 17:03 UTC; Posted 23 July 2008
Posted to: Molecular Cell Biology
Systems biology of energetic and atomic costs in the yeast transcriptome, proteome, and metabolome
Background: Every protein has a variable atomic and energetic cost to the cell based on the synthesis of its constituent amino acids. Quantifying the cost of amino acid synthesis is challenging, ho…
Received 21 July 2008 15:09 UTC; Posted 22 July 2008
Posted to: Genetics & Genomics, Molecular Cell Biology, Bioinformatics
Activation of Ras-ERK pathway by Fgf8 and its downregulation by Sprouty2 for the isthmus organizing activity
In the previous studies, we showed that strong Fgf8 signaling activates the Ras-ERK pathway to induce cerebellum. Here, we show importance of negative regulation of this pathway. ‘Prolonged’ activa…
Received 18 July 2008 06:30 UTC; Posted 18 July 2008
Posted to: Developmental Biology, Molecular Cell Biology, Neuroscience
Check Your Data Freedom: A Taxonomy to Assess Life Science Database Openness
Molecular biology data are subject to terms of use that vary widely between databases and curating institutions. This research presents a taxonomy of contractual and technical restrictions applicab…
Received 17 July 2008 15:28 UTC; Posted 18 July 2008
Posted to: Molecular Cell Biology, Bioinformatics
Angiogenesis and Vasculogenesis at 7-Day of Reperfused Acute Myocardial Infarction
Objectives This study is to investigate the angiogenesis and vasculogenesis at the first week of reperfused acute myocardial infarction (AMI).Methods 16 of mini-swines (20 to 30 Kg) were rand…
Received 10 July 2008 17:05 UTC; Posted 11 July 2008
Posted to: Molecular Cell Biology, Bioinformatics
