Molecular Cell Biology
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Evidence of existence of totally different types of ribosomes in intermediate animals
In all organisms, messenger-directed protein synthesis is catalyzed by ribonucleoprotein particles called ribosomes. A ribosome is typically composed of one small and one large subunit which contai…
Received 07 December 2008 17:49 UTC; Posted 11 December 2008
Posted to: Genetics & Genomics, Microbiology, Molecular Cell Biology
Adenovirus-mediated transfer of siRNA against survivin enhances the radiosensitivity of human non-small cell lung cancer cells
Expression of survivin has been reported to be correlated with shorter survival in patients with non-small cell lung cancer (NSCLC), and overexpression of survivin may lead to radioresistance in va…
Received 01 December 2008 17:22 UTC; Posted 02 December 2008
Posted to: Cancer, Molecular Cell Biology
Gene Expression Profiling of the Hepatic Transcriptome in Presence of TNF-alpha
Diabetes mellitus, often simply termed Diabetes, is a syndrome characterized by disordered metabolism and high blood sugar. It is caused due to low levels of insulin hormone or from abnormal resist…
Received 18 November 2008 06:56 UTC; Posted 18 November 2008
Posted to: Molecular Cell Biology
Gene Transfer of Calcitonin Gene-Related Peptide Inhibits Macrophages and Inflammatory Mediators in Vein Graft Disease
Vein graft disease is a chronic inflammatory disease and limits the late results of coronary revascularization. Calcitonin gene-related peptide (CGRP) inhibits macrophages infiltrated and inflammat…
Received 31 October 2008 18:14 UTC; Posted 06 November 2008
Posted to: Molecular Cell Biology
Memristive model of amoeba’s learning
Recently, behavioural intelligence of the plasmodia of the true slime mold has been demonstrated. It was shown that a large amoeba-like cell Physarum polycephalum subject to a pattern of periodic e…
Received 22 October 2008 23:13 UTC; Posted 24 October 2008
Posted to: Ecology, Molecular Cell Biology, Bioinformatics
Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11β-hydroxysteroid dehydrogenase 1
Intracellular glucocorticoid reactivation is catalyzed by 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), which functions predominantly as a reductase in cells expressing hexose-6-phosphat…
Received 22 October 2008 18:32 UTC; Posted 22 October 2008
Posted to: Molecular Cell Biology, Pharmacology, Bioinformatics
Principal basis for enzyme power
The reaction rate enhancement that enzymes produce had not been fully appreciated. The object of the article is to present the mechanism of the enormous catalytic power of the enzymes. I conclude t…
Received 17 October 2008 16:08 UTC; Posted 24 October 2008
Posted to: Chemistry, Molecular Cell Biology
ARHI (DIRAS 3), an Imprinted Tumor Suppressor Gene, Binds to Importins, and Blocks Nuclear Translocation of Stat3
ARHI (DIRAS3) is an imprinted tumor suppressor gene whose expression is lost in the majority of breast and ovarian cancers. Unlike its homologs Ras and Rap, ARHI functions as a tumor suppressor. Ou…
Received 12 October 2008 12:15 UTC; Posted 17 October 2008
Posted to: Molecular Cell Biology
The monoclonal antibody nBT062 conjugated to maytansinoids has potent and selective cytotoxicity against CD138 positive multiple myeloma cells in vitro and in vivo
CD138 (Syndecan1) is highly expressed on multiple myeloma (MM) cells. In this study, we examined the anti-MM effect of murine/human chimeric CD138-specific monoclonal antibody (mAb) nBT062 conjugat…
Received 07 October 2008 22:33 UTC; Posted 08 October 2008
Posted to: Cancer, Molecular Cell Biology
Yeast Features: Identifying Significant Features Shared Among Yeast Proteins for Functional Genomics
BackgroundHigh throughput yeast functional genomics experiments are revealing associations among tens to hundreds of genes using numerous experimental conditions. To fully understand how the iden…
Received 18 September 2008 23:22 UTC; Posted 19 September 2008
Posted to: Molecular Cell Biology, Bioinformatics
