Molecular Cell Biology
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Nucleosome-mediated cooperativity between transcription factors
Cooperative binding of transcription factors (TFs) to cis-regulatory regions (CRRs) is essential for precision of gene expression in development and other processes. The classical model of cooperat…
Received 16 January 2009 23:21 UTC; Posted 21 January 2009
Posted to: Developmental Biology, Genetics & Genomics, Molecular Cell Biology, Bioinformatics
Neuronal plasticity: cell-based strategy for target identification and validation
While growing neurites are relatively plastic during development, their plasticity levels drop rapidly as neurons mature and become integrated into neuronal networks. As a consequence, the central …
Received 13 January 2009 02:16 UTC; Posted 13 January 2009
Posted to: Molecular Cell Biology, Neuroscience, Pharmacology
Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to altered dysbindin-1 gene expression
DTNBP1 (dystrobrevin binding protein 1) remains one of the top candidate genes in schizophrenia. Reduced expression of this gene and the protein it encodes, dysbindin-1, has been reported in the do…
Received 13 January 2009 01:19 UTC; Posted 13 January 2009
Posted to: Genetics & Genomics, Molecular Cell Biology, Neuroscience
Rabbit Muscle Actin Polymerization changes by Ultraviolet –B radiation
Increase in Ultraviolet-B flux from the Sun has the potential to alter the protein in mammals. Rabbit muscle was processed and filtered to extract G-actin, which was tested for its protein concentr…
Received 08 January 2009 16:27 UTC; Posted 15 January 2009
Posted to: Molecular Cell Biology
Frizzled Proteins are bona fide G Protein-Coupled Receptors
Receptors of the Frizzled family initiate Wnt ligand-dependent signaling controllingmultiple steps in organism development and highly conserved in evolution.Misactivation of the Wnt/Frizzled si…
Received 08 January 2009 16:38 UTC; Posted 09 January 2009
Posted to: Cancer, Developmental Biology, Molecular Cell Biology, Pharmacology
Fundamentally different strategies for transcriptional regulation are revealed by analysis of binding motifs
To regulate a particular gene, a transcription factor (TF) needs to bind a specific genome location. How is this genome address specified amid the presence of ~106-109 decoy sites? Our analysis…
Received 27 December 2008 20:53 UTC; Posted 28 December 2008
Posted to: Genetics & Genomics, Molecular Cell Biology, Bioinformatics, Evolutionary Biology
The Entropic Landscape of proteins revealing protein folding mechanism
It has long since been a mystery why most proteins fold within a flash of time into particular structures out of astronomically large numbers of possible conformations. Even more confusing is that …
Received 25 December 2008 10:15 UTC; Posted 28 December 2008
Posted to: Biotechnology, Molecular Cell Biology, Bioinformatics
Heat shock transcription factor 1 preserves cardiac angiogenesis and adaptation during pressure overload
To examine how heat shock transcription factor 1 (HSF1) protects against maladaptive hypertrophy during pressure overload, we subjected HSF1 transgenic (TG), knockout (KO) and wild type (WT) mice t…
Received 24 December 2008 13:51 UTC; Posted 24 December 2008
Posted to: Molecular Cell Biology
The Heterochromatin Protein 1 positively regulates euchromatic gene expression by RNA binding
HP1 is a well known conserved protein involved in heterochromatin formation and gene silencing in different species including humans1-4. A general model has been proposed for heterochromatin format…
Received 19 December 2008 19:52 UTC; Posted 22 December 2008
Posted to: Genetics & Genomics, Molecular Cell Biology
Kinetic control of eukaryotic chromatin structure by recursive topological restraints
Chromatin structure undergoes many changes during the cell cycle and in response to regulatory events. A basic unit of chromatin organization is the nucleosome core particle. However, very little i…
Received 17 December 2008 18:09 UTC; Posted 18 December 2008
Posted to: Developmental Biology, Genetics & Genomics, Molecular Cell Biology
