Molecular Cell Biology
Sign up for alerts
Phylogeny of conserved adenines in linkers of Group-I introns
We have analyzed the linkers in group-I introns, a characteristic region that is crucial to the folding and splicing process of the folded RNA, in seventy sequences spreading across r-RNA, t-RNA an…
Received 28 February 2009 19:36 UTC; Posted 03 March 2009
Posted to: Molecular Cell Biology, Bioinformatics, Evolutionary Biology
The Necessity of Darwin
February 12th, 2009 was Charles Darwin’s 200th birthday, and November 2009 represents the 150th anniversary of the publication of his transformative book, The Origin of Species. It seems a good tim…
Received 19 February 2009 10:12 UTC; Posted 23 February 2009
Posted to: Genetics & Genomics, Molecular Cell Biology, Evolutionary Biology
Cooperative effect of ribosomal protein s19 and Pim-1 kinase on murine c-Myc expression and myeloid/erythroid cellularity
Diamond Blackfan anemia (DBA) is a bone marrow failure syndrome associated with heterozygous mutations in the ribosomal protein S19 (RPS19) gene in a subgroup of patients. One of the interacting pa…
Received 18 February 2009 13:56 UTC; Posted 20 February 2009
Posted to: Molecular Cell Biology
ER localized bestrophin1 activates Ca2+ dependent ion channels TMEM16A and SK4
Bestrophins form Ca2+ activated Cl- channels and regulate intercellular Ca2+ signaling1. We demonstrate that bestrophin 1 is localized in the endoplasmic reticulum (ER), where it physically interac…
Received 18 February 2009 12:14 UTC; Posted 24 February 2009
Posted to: Molecular Cell Biology
Myosin II isoforms with separate but linked functions determine the fate of lamellipodia extension during cell spreading
Non-muscle myosin II role has been implicated in the extension of lamellipodia, a critical step in the initiation of directed cell migration, invasion and other cellular processes, but the mechanis…
Received 11 February 2009 23:38 UTC; Posted 18 February 2009
Posted to: Cancer, Microbiology, Molecular Cell Biology
Evolutionary descent of prion genes from a ZIP metal ion transport ancestor
In the more than 20 years since its discovery, both the phylogenetic origin and cellular function of the prion protein (PrP) have remained enigmatic. Insights into the function of PrP may be obtain…
Received 10 February 2009 21:16 UTC; Posted 10 February 2009
Posted to: Genetics & Genomics, Molecular Cell Biology, Evolutionary Biology
Genome-wide association study identifies FUT8 and ESR2 as co-regulators of a bi-antennary N-linked glycan A2 (GlcNAc2Man3GlcNAc2) in human plasma proteins
HPLC analysis of N-glycans quantified levels of the biantennary glycan (A2) in plasma proteins of 924 individuals. Subsequent genome-wide association study (GWAS) using 317,503 single nucleotide po…
Received 10 February 2009 02:55 UTC; Posted 10 February 2009
Posted to: Genetics & Genomics, Molecular Cell Biology
Effect of Stimulators upon Human Hepatic Adenylate Cyclase Activity: A Tool of Nitroimidazole Cytotoxicity Assessment
Nitroimidazole is an antibiotic and radiosensitizer chemical with great potentials in imaging. The hepato-cytoxicity evaluation of nitroimidazole and possible energy status changes in liver cells d…
Received 05 February 2009 23:21 UTC; Posted 09 February 2009
Posted to: Molecular Cell Biology, Pharmacology
Deficiency of interleukin-1 receptor antagonist causes spontaneous femoral artery aneurysms
Interleukin (IL) -1, a proinflammatory cytokine, increases in aneurysm, and the IL-1 receptor antagonist (IL-1Ra) modulates IL-1 activity endogenously. We show here that IL-1Ra-deficiency in hemato…
Received 28 January 2009 15:07 UTC; Posted 29 January 2009
Posted to: Molecular Cell Biology
Reputation, authority and incentives. Or: How to get rid of the Impact Factor
A short intro into the impact factor and its limitations and potential successors.
Received 18 January 2009 19:55 UTC; Posted 21 January 2009
Posted to: Chemistry, Molecular Cell Biology, Bioinformatics
