Molecular Cell Biology
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Sugar-based synthesis of Tamiflu and its inhibitory effects on cell secretion
Tamiflu is currently the most effective drug for the treatment of influenza. But the unmet supply and side effects of this drug demand urgent solutions. In this article, a practical synthesis of Ta…
Received 19 June 2009 16:47 UTC; Posted 22 June 2009
Posted to: Chemistry, Molecular Cell Biology
MIF-AMPK cascades
Withdrawn for publication
Received 11 June 2009 21:04 UTC; Posted 12 June 2009
Posted to: Molecular Cell Biology, Pharmacology
Rethinking Leucine Zipper – a ubiquitous signal transduction motif
In this essay we attempt to reconsider the concept of the “Leucine Zipper” (LZ) protein oligomerization motif. Reasoning on the wealth of existing data, we suggest that despite of the structural si…
Received 22 May 2009 07:26 UTC; Posted 22 May 2009
Posted to: Cancer, Immunology, Molecular Cell Biology, Bioinformatics
Ablation of Galectin-12 Results in Enhanced Lipolysis and Reduced Adiposity in Mice
Aside from leptin, galectin-12 is the only other gene exclusively expressed in mouse adipose tissue, suggesting an important role in energy homeostasis. The breakdown of triglycerides, or lipolysis…
Received 06 May 2009 00:30 UTC; Posted 06 May 2009
Posted to: Molecular Cell Biology
Reflect: Augmented Browsing for the Life Scientist
Anyone who regularly reads life science literature often comes across names of genes, proteins, or small molecules that they would like to know more about. To make this process easier, we have deve…
Received 02 May 2009 01:44 UTC; Posted 04 May 2009
Posted to: Biotechnology, Chemistry, Genetics & Genomics, Molecular Cell Biology, Bioinformatics
In silico Protein Structural Modeling and Active binding site Evaluation of Streptococcus pneumoniae
Structure function relation of glucose kinese in Streptococcus pneumoniae. However, a solved structure for Streptococcus pneumoniae glucose kinese is not available at the protein data bank. Gluco…
Received 30 April 2009 11:55 UTC; Posted 06 May 2009
Posted to: Molecular Cell Biology, Bioinformatics
Visualization of the Phosphoproteomic Data from AfCS with the Google Motion Chart Gadget
Results from multivariate molecular biological experiments become increasingly complex. Hence, the challenge of projecting high-dimensional data onto few dimensions for effective data visualization…
Received 16 April 2009 15:39 UTC; Posted 16 April 2009
Posted to: Biotechnology, Molecular Cell Biology, Bioinformatics
Signaling via Alk5 Controls Ontogeny of Lung Clara Cells
Clara cells, together with ciliated and pulmonary neuroendocrine cells, make up the epithelium of the bronchioles along the conducting airways. Clara cells are also known as Progenitor/Stem cells d…
Received 07 April 2009 18:29 UTC; Posted 08 April 2009
Posted to: Genetics & Genomics, Molecular Cell Biology
Glucose-6-phosphate-dehydrogenase deficiency as a risk factor in proliferative disorder development
Glucose-6-phosphate dehydrogenase (G6PD) is an important site of metabolic control in the pentose phosphate pathway (PPP) which provides reducing power (NADPH) and pentose phosphates. The former is…
Received 29 March 2009 10:51 UTC; Posted 30 March 2009
Posted to: Molecular Cell Biology
Identification of the prebiotic translation apparatus within the contemporary ribosome
A structural element that could have existed independently in the prebiotic era was identified at the active site of the contemporary ribosome. It is suggested to have functioned as a proto-ribosom…
Received 04 March 2009 17:28 UTC; Posted 18 March 2009
Posted to: Molecular Cell Biology, Evolutionary Biology
