Molecular Cell Biology
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Extragenic Suppression analysis of TS mutations using Sec61p
During synthesis, secretory and membrane proteins are cotranslationally translocated into the lumen of the endoplasmic reticulum through an aqueous gated channel. Proper folding, degradation, and t…
Received 08 August 2007 15:16 UTC; Posted 08 August 2007
Posted to: Molecular Cell Biology
Direct fluorophore conjugation to genomic DNA for microarray-based epigenomic profiling
A methodology for microarray based epigenomic profiling is presented. The method relies on platinum-based fluorescence labeling reagents for direct (non-enzymatic) labeling of DNA and RNA. This is …
Received 12 July 2007 16:09 UTC; Posted 12 July 2007
Posted to: Biotechnology, Cancer, Chemistry, Molecular Cell Biology
Quantification of Cell Movement Reveals Distinct Edge Motility Types During Cell Spreading
Actin-based motility is central to cellular processes such as migration, bacterial engulfment, and cancer metastasis, and requires precise spatial and temporal regulation of the cytoskeleton. We st…
Received 08 July 2007 07:36 UTC; Posted 09 July 2007
Posted to: Biotechnology, Molecular Cell Biology
Characterization of Fut10 and Fut11, Putative Alpha-1-3/4 Fucosyltransferase Genes Important for Vertebrate Development
Two new, putative alpha-1-3/4 fucosyltransferases (α1-3/4 Fuc-Ts), Fuc-TX and Fuc-TXI, were identified in the vertebrate genome and transcriptome sequence databases through sequence homology-...
Received 20 June 2007 20:53 UTC; Posted 20 June 2007
Posted to: Developmental Biology, Molecular Cell Biology
Folding pathway of the B1 domain of protein G explored by a multiscale modeling
The understanding of the folding mechanisms of single domain proteins is an essential step in the understanding of protein folding in general. Recently, we developed a mesoscopic CABS protein model…
Received 20 June 2007 13:55 UTC; Posted 20 June 2007
Posted to: Molecular Cell Biology, Bioinformatics
PIM1-dependent phosphorylation of Histone H3 at Serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation.
The serine/threonine kinase PIM1, cooperates with MYC in cell cycle progression and tumorigenesis. However, the nature of this cooperation remains elusive. Here we show that PIM1 contributes to the…
Received 19 June 2007 14:34 UTC; Posted 20 June 2007
Posted to: Cancer, Molecular Cell Biology
Intact mitochondria migrate in membrane tubular network connections formed between human stem cells
The hypothesis of mitochondrial transfer between eukaryotic animal cells is intriguing, although its route of action and physiological role is unknown. Our goal was to examine intercellular connect…
Received 12 June 2007 16:02 UTC; Posted 13 June 2007
Posted to: Molecular Cell Biology
Genes2Networks: Connecting Lists of Proteins by Using Background Literature-based Mammalian Networks
In recent years, in-silico literature-based mammalian protein-protein interaction network datasets have been developed. These datasets contain binary interactions extracted manually from legacy exp…
Received 07 June 2007 15:27 UTC; Posted 08 June 2007
Posted to: Biotechnology, Molecular Cell Biology, Bioinformatics
Intracellular Regulatory Networks are close to Monotone Systems
Several meso-scale biological intracellular regulatory networks that have specified directionality of interactions have been recently assembled from experimental literature. Directed networks where…
Received 23 January 2007 16:57 UTC; Posted 23 January 2007
Posted to: Molecular Cell Biology, Bioinformatics
Dynamic Topology of Biological Networks
The mammalian cell can be represented as a large modular network that consists of a central signal network that interacts with and regulates multiple cellular machines that are responsible for phen…
Received 23 January 2007 16:48 UTC; Posted 23 January 2007
Posted to: Molecular Cell Biology, Neuroscience, Pharmacology, Bioinformatics
