Molecular Cell Biology
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Diagnostic robustness of DNA microarrays in the classification of acute leukemia
Countless statistical methods have been described for the analysis of DNA microarrays, and each yields distinct results. This raises the question whether DNA microarrays are robust diagnostic tools…
Received 20 September 2007 15:34 UTC; Posted 26 September 2007
Posted to: Biotechnology, Cancer, Genetics & Genomics, Molecular Cell Biology, Pharmacology, Bioinformatics
Modeling of ARS-interacting multifunctional proteins p18 and p38.
ARS-interacting multifunctional proteins (auxiliary components) – are nonezymatic proteins, associated with aminoacyl-tRNA synthetases – enzymes that catalyse the joining of amino acids with their …
Received 19 September 2007 10:15 UTC; Posted 19 September 2007
Posted to: Molecular Cell Biology, Bioinformatics
DNA expression microarrays may be the wrong tool to identify biological pathways
DNA microarray expression signatures are expected to provide new insights into patho- physiological pathways. Numerous variant statistical methods have been described for each step of the signal an…
Received 18 September 2007 13:09 UTC; Posted 19 September 2007
Posted to: Biotechnology, Genetics & Genomics, Molecular Cell Biology, Pharmacology, Bioinformatics
Keratinocytes from human skin respond as typical immune cells after the stimulation with Trichophyton rubrum
Trichophyton rubrum is the main agent causing dermatophytosis (1). Keratinocytes areconsidered to be the first physical barrier of defense against pathogens (2). But notonly a physical barrie…
Received 06 September 2007 13:32 UTC; Posted 06 September 2007
Posted to: Immunology, Microbiology, Molecular Cell Biology
Novel protein antigen (JHP940) from the genomic plasticity region of Helicobacter pylori induces TNF-alpha and Interleukin- 8 secretion by human macrophages
Plasticity region of the H. pylori genome comprises strain specific gene loci. We performed genotyping and functional biology of one such locus (jhp940) that was previously found to be functionally…
Received 30 August 2007 14:28 UTC; Posted 30 August 2007
Posted to: Immunology, Microbiology, Molecular Cell Biology
Analysis of circadian pattern reveals tissue-specific alternative transcription in leptin signaling pathway
BackgroundIt has been previously reported that most mammalian genes display a circadian oscillation in their baseline expression. Consequently, the phase and amplitude of each component of a si…
Received 29 August 2007 18:50 UTC; Posted 30 August 2007
Posted to: Molecular Cell Biology, Pharmacology, Bioinformatics
Hierarchical coexistence of universality and diversity controls robustness and multi-functionality in intermediate filament protein networks
Proteins constitute the elementary building blocks of a vast variety of biological materials such as cellular protein networks, spider silk or bone, where they create extremely robust, multi-functi…
Received 25 August 2007 20:14 UTC; Posted 27 August 2007
Posted to: Biotechnology, Chemistry, Ecology, Molecular Cell Biology
Opposite effects of two zinc(II) dithiocarbamates on NF-kB pathway
Inhibiting nuclear factor-kappaB (NF-kB) activation in anticancer and antiinflammatory therapy is of topical interest. Current research in molecular biology has dramatically advanced in the underst…
Received 15 August 2007 11:21 UTC; Posted 16 August 2007
Posted to: Cancer, Chemistry, Molecular Cell Biology, Pharmacology
Solvent Induced Disulfide Bond Formation in 2,5-dimercapto-1,3,4-thiadiazole
Disulfide bond formation is the decisive event in the protein folding to determine the conformation and stability of protein. To achieve this disulfide bond formation in vitro, we took 2,5-dimercap…
Received 15 August 2007 11:01 UTC; Posted 15 August 2007
Posted to: Chemistry, Molecular Cell Biology
Synergistic Induction of NR4A Orphan Nuclear Receptors by LPS and cAMP in Murine Macrophage Cells
Although NR4A orphan nuclear receptors have been implicated in inflammatory gene expression and atherosclerosis, there is little information regarding their regulation by combinations of stimuli li…
Received 09 August 2007 12:19 UTC; Posted 10 August 2007
Posted to: Molecular Cell Biology
