Microbiology
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Is the infection/latency/reactivation cycle of viruses an oncogenic engine?
Human oncogenic viruses are defined as necessary but not sufficient to initiate cancer. Experimental evidence suggests that the oncogenic potential of a virus is effective only in cells that have a…
Received 31 October 2007 16:53 UTC; Posted 31 October 2007
Posted to: Cancer, Microbiology, Molecular Cell Biology
Streptomyces sp. as predators of bacteria
Background: The ecological role of actinomycetes and their secondary metabolites is not yet completely understood. Hypothesis: Actinomycetes and Streptomyces sp. in particular, are non-obligate p…
Received 30 October 2007 14:36 UTC; Posted 01 November 2007
Posted to: Biotechnology, Ecology, Microbiology
A Simple, Rapid Method for Extracting Large Plasmid DNA from Bacteria
We are studying the lateral transfer of transmissible antibiotic resistance plasmids among stream bacteria impacted by fecal runoff from poultry and cattle. Such plasmids are typically large (ca. 4…
Received 23 October 2007 21:58 UTC; Posted 24 October 2007
Posted to: Biotechnology, Genetics & Genomics, Microbiology
Internal ribosomal entry site lacks secondary structure
The search for mechanisms of translational regulation has yielded many experimentally identified internal ribosome entry sites (IRES). Because of the lack of sequence similarity among the experimen…
Received 23 October 2007 14:28 UTC; Posted 23 October 2007
Posted to: Microbiology, Molecular Cell Biology, Bioinformatics
Antimicrobial activity of skin secretions isolated from Indian toad, Bufo melanostictus Schneider 1799
Amphibians like toads have been known to secrete antimicrobial secretions outside their body into their environments, through skin pores and parotid glands. Toad skin-secretions contain four types …
Received 03 October 2007 20:05 UTC; Posted 03 October 2007
Posted to: Microbiology
Transparent Exopolymer Particles (TEP): an overlooked factor in the process of biofilm formation in aquatic environments
We hypothesize that transparent exopolymer particles (TEP), present in high concentrations in most sea and freshwaters, are critical agents for biofilm initiation and development in many natural an…
Received 28 September 2007 11:05 UTC; Posted 28 September 2007
Posted to: Biotechnology, Microbiology
Stomatin-like Protein 2 Links Mitochondria to T-Cell Receptor Signalosomes at the Immunological Synapse and Enhances T-Cell Activation
T cell activation through the antigen receptor (TCR) requires sustained signalling from microclusters in the peripheral region of the immunological synapse (IS). The bioenergetics of such prolonged…
Received 21 September 2007 15:21 UTC; Posted 21 September 2007
Posted to: Immunology, Microbiology, Molecular Cell Biology
Concurrent Acquisition of a Single Nucleotide Polymorphism in Diverse Influenza H5N1 Clade 2.2 Sub-clades
Highly pathogenic Influenza A H5N1 was first identified in Guangdong Province in 1996, followed by human cases in Hong Kong in 1997. The number of confirmed human cases now exceeds 300, and the ass…
Received 10 September 2007 12:42 UTC; Posted 12 September 2007
Posted to: Biotechnology, Chemistry, Ecology, Genetics & Genomics, Immunology, Microbiology, Bioinformatics
Keratinocytes from human skin respond as typical immune cells after the stimulation with Trichophyton rubrum
Trichophyton rubrum is the main agent causing dermatophytosis (1). Keratinocytes areconsidered to be the first physical barrier of defense against pathogens (2). But notonly a physical barrie…
Received 06 September 2007 13:32 UTC; Posted 06 September 2007
Posted to: Immunology, Microbiology, Molecular Cell Biology
Novel protein antigen (JHP940) from the genomic plasticity region of Helicobacter pylori induces TNF-alpha and Interleukin- 8 secretion by human macrophages
Plasticity region of the H. pylori genome comprises strain specific gene loci. We performed genotyping and functional biology of one such locus (jhp940) that was previously found to be functionally…
Received 30 August 2007 14:28 UTC; Posted 30 August 2007
Posted to: Immunology, Microbiology, Molecular Cell Biology
