Microbiology
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Preincision Processing of Cyclobutane Pyrimidine Dimers in Escherichia coli
In both prokaryotes and eukaryotes cyclobutane pyrimidine dimers (CPD) formed by UV-irradiation are repaired mainly by the nucleotide excision repair (NER) pathway. Evidence has been presented that…
Received 24 March 2008 15:58 UTC; Posted 27 March 2008
Posted to: Genetics & Genomics, Microbiology, Molecular Cell Biology
A Bacterial Enzyme Catalyzing Double Reduction of a β,δ-Diketo Ester with Unprecedented Stereoselectivity
Various ketoreductases exclusively participate in all common biological events, and they are a class of important biocatalysts for the production of chiral alcohols. While many types of ketoreducta…
Received 20 March 2008 08:02 UTC; Posted 20 March 2008
Posted to: Biotechnology, Chemistry, Microbiology
M. tuberculosis interactome analysis unravels potential pathways to drug resistance
Drug resistance is a major problem for combating tuberculosis. Lack of understanding of how resistance emerges in bacteria upon drug treatment limits our ability to counter resistance. By analysis …
Received 11 March 2008 04:34 UTC; Posted 11 March 2008
Posted to: Microbiology, Bioinformatics
Tuberculosis vaccine strain Mycobacterium bovis BCG Russia is a natural recA mutant
The current tuberculosis vaccine is a live vaccine derived from Mycobacterium bovis and attenuated by serial in vitro passaging. All vaccine substrains in use stem from one source, strain Bacil…
Received 07 February 2008 10:54 UTC; Posted 07 February 2008
Posted to: Genetics & Genomics, Microbiology, Evolutionary Biology
Azadirachta indica induced suppression of Mycobacterium tuberculosis secreted proteins in human monocyte
The H37Rv strain of MTB was grown in modified Sauton’s medium till mid-log phase. Peripheral blood mononuclear cells (PBMC) were isolated by density gradient sedimentation on Ficoll-Paque separatio…
Received 01 February 2008 12:38 UTC; Posted 01 February 2008
Posted to: Microbiology, Molecular Cell Biology
Allicin from garlic suppresses TNF-α and augments IFN-γ expressions in monocyte cultures from patients with Vaginitis
Objective: We tried to explore beneficial effects of allicin- a natural antioxidant from garlic in the possible management of vaginitis. Methods: Peripheral blood mononuclear cells (PBMC’s) were …
Received 01 February 2008 09:49 UTC; Posted 01 February 2008
Posted to: Immunology, Microbiology, Molecular Cell Biology
Role and immunomodulatory profile of histamine receptors by H1 and H2 antagonists
The present study was designed to delineate the immunomodulatory role of histamine receptors (H1- and H2-) on induction of antibody response to sheep red blood cells (SRBC), as well as the antibody…
Received 29 January 2008 10:31 UTC; Posted 29 January 2008
Posted to: Immunology, Microbiology, Pharmacology
The spread of antimalarial drug resistance: A mathematical model with practical implications for ACT drug policies
Most malaria-endemic countries are implementing a change in antimalarial drug policy to artemisinin combination therapy (ACT). The impact of different drug choices and implementation strategies is …
Received 24 January 2008 05:15 UTC; Posted 24 January 2008
Posted to: Microbiology, Pharmacology, Bioinformatics
In Silico Docking Analysis of Peptide Deformylase (PDF) – A Novel Target for Prophylaxis of Leptospirosis
Peptide deformylase (PDF) is a metalloproteinase and executes an essential step in the maturation of proteins in eubacteria, by removing the formyl group from the N-terminal methionine residue of r…
Received 16 January 2008 06:21 UTC; Posted 21 January 2008
Posted to: Microbiology, Pharmacology, Bioinformatics
Water and the Biology of Prions and Plaques
This is an attempt to account for the insolubility and/or aggregation of prions and plaques in terms of a model of water consisting of an equilibrium between high densit…
Received 01 December 2007 11:53 UTC; Posted 17 December 2007
Posted to: Microbiology, Molecular Cell Biology
