Immunology
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siRNA knockdown of SPHK1 in vivo protects mice from systemic, type-I Allergy.
Systemic anaphylaxis is considered to be a typical immediate hypersensitivity response, determined by the activation of immune cells,via antigen-induced aggregation of IgE-sensitized FcεRI cells….
Received 27 September 2007 14:31 UTC; Posted 27 September 2007
Posted to: Immunology, Molecular Cell Biology, Pharmacology
The Immune Response in Patients with SARS: differential gene expression profiling.
Severe acute respiratory syndrome (SARS) emerged in 2003, as a new epidemic form of life-threatening infection. As of 26th September 2003, there were 8422 cases of SARS from 29 countries with 908 d…
Received 27 September 2007 14:19 UTC; Posted 27 September 2007
Posted to: Immunology, Molecular Cell Biology, Bioinformatics
Stomatin-like Protein 2 Links Mitochondria to T-Cell Receptor Signalosomes at the Immunological Synapse and Enhances T-Cell Activation
T cell activation through the antigen receptor (TCR) requires sustained signalling from microclusters in the peripheral region of the immunological synapse (IS). The bioenergetics of such prolonged…
Received 21 September 2007 15:21 UTC; Posted 21 September 2007
Posted to: Immunology, Microbiology, Molecular Cell Biology
Concurrent Acquisition of a Single Nucleotide Polymorphism in Diverse Influenza H5N1 Clade 2.2 Sub-clades
Highly pathogenic Influenza A H5N1 was first identified in Guangdong Province in 1996, followed by human cases in Hong Kong in 1997. The number of confirmed human cases now exceeds 300, and the ass…
Received 10 September 2007 12:42 UTC; Posted 12 September 2007
Posted to: Biotechnology, Chemistry, Ecology, Genetics & Genomics, Immunology, Microbiology, Bioinformatics
Keratinocytes from human skin respond as typical immune cells after the stimulation with Trichophyton rubrum
Trichophyton rubrum is the main agent causing dermatophytosis (1). Keratinocytes areconsidered to be the first physical barrier of defense against pathogens (2). But notonly a physical barrie…
Received 06 September 2007 13:32 UTC; Posted 06 September 2007
Posted to: Immunology, Microbiology, Molecular Cell Biology
Pregnancy Obstructs Involution Stage II of the Mammary Gland in Cows: General Biological Implications
BackgroundRepeated research findings over the last 4 decades show that involution of mammary glands in dairy cows did not regress to same extend as that noticed in other mammalian species.*...
Received 03 September 2007 11:42 UTC; Posted 03 September 2007
Posted to: Cancer, Developmental Biology, Immunology
Novel protein antigen (JHP940) from the genomic plasticity region of Helicobacter pylori induces TNF-alpha and Interleukin- 8 secretion by human macrophages
Plasticity region of the H. pylori genome comprises strain specific gene loci. We performed genotyping and functional biology of one such locus (jhp940) that was previously found to be functionally…
Received 30 August 2007 14:28 UTC; Posted 30 August 2007
Posted to: Immunology, Microbiology, Molecular Cell Biology
Effective Sample Size: Quick Estimation of the Effect of Related Samples in Genetic Case-Control Association Analyses
Correlated samples have been frequently avoided in case-controlgenetic association studies in part because the methods for handling them are either noteasily implemented or not widely known….
Received 09 July 2007 21:41 UTC; Posted 10 July 2007
Posted to: Genetics & Genomics, Immunology
Review of Immunoinformatic approaches to in-silico B-cell epitope prediction
In this paper, the current state of in-silico, B-cell epitope prediction is discussed. Recommendations for improving some of the approaches encountered are outlined, along with the presentation o…
Received 05 July 2007 03:01 UTC; Posted 05 July 2007
Posted to: Immunology, Bioinformatics
Evolution of malaria virulence in cross-generation transmission through selective immune pressure
Theoretical arguments and some mathematical models of host-parasite coevolution (e.g. [1- 6]) suggest host immunity as the driving source for the evolution of parasite virulence. Imperfect vaccines…
Received 23 June 2007 19:32 UTC; Posted 25 June 2007
Posted to: Immunology, Bioinformatics, Evolutionary Biology
