Immunology
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Interleukin-10 containing normal human serum inhibits granzyme B release but not perforin release from alloreactive and EBV-specific T cell clones
Interleukin-10 (IL-10), also known as cytokine synthesis inhibitory factor, has pleiotropic effects in immunoregulation and inflammation. It is capable of inhibiting synthesis of pro-inflammatory c…
Received 05 December 2007 07:51 UTC; Posted 07 December 2007
Posted to: Immunology
Artificial Antigen Presenting Cells With Preclustered anti-CD28/-CD3/-LFA-1 Monoclonal Antibodies Are Highly Effective To Induce The Ex-Vivo Expansion Of Functional Human Antitumor T Cells
Effective adoptive T cell therapy requires the ex vivo generation of functional T lymphocytes with a long lifespan in vivo. We evaluated in vitro T cell expansion by artificial antigen presen…
Received 24 October 2007 10:43 UTC; Posted 24 October 2007
Posted to: Biotechnology, Cancer, Immunology
Upstream Stimulatory Factor (USF) and CCAAT/Enhancer Binding Protein δ (C/EBPδ) Compete for overlapping Sites in the Negative Regulatory Region of the HIV-1 LTR
Human immunodeficiency virus type 1 (HIV-1) is a human retrovirus and the causative agent of the acquired immunodeficiency syndrome. Genetic analysis has revealed that the HIV-1 LTR contains a pote…
Received 08 October 2007 15:49 UTC; Posted 09 October 2007
Posted to: Immunology, Molecular Cell Biology
Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer: a novel mechanism for enhancing specific antigen presentation
The B cell antigen receptor (BCR) efficiently facilitates the capture and processing of a specific antigen for presentation on MHC class II molecules to antigen specific CD4+ T cells (1). Despite t…
Received 05 October 2007 06:18 UTC; Posted 05 October 2007
Posted to: Immunology
Kinase independent inhibition of NFκB transcriptional activity by GRK5 through IκBα stabilization.
Members of the G protein receptor kinase (GRK) family that regulates receptor desensitization and members of the nuclear transcription factors family NFκB have been recently and convincingly …
Received 29 September 2007 07:20 UTC; Posted 01 October 2007
Posted to: Immunology, Molecular Cell Biology
The Roles of Membrane Rafts in CD32A-Mediated Phagocytosis
Membrane rafts are highly dynamic heterogeneous sterol- and sphingolipid-rich micro-domains on cell surfaces. They are generally believed to provide residency for cell surface molecules (e.g., adhe…
Received 28 September 2007 20:03 UTC; Posted 28 September 2007
Posted to: Immunology, Molecular Cell Biology
Tumor necrosis factor and caspase in response to soluble or microparticle-incorporated drugs in Mycobacterium tuberculosis infection
We compared the effects of microparticles (MP) containig anti-tubercular drugs and those of the drugs themselves on the host macrophage (MΦ) response to infection with Mycobacterium tuberculosis H3…
Received 28 September 2007 17:12 UTC; Posted 30 September 2007
Posted to: Immunology, Pharmacology
Genome activity profiling of monomeric-IgE and Fc-epsilon-RI-aggregation on human mast cells reveals a complex network of genes involved in inflammatory responses.
Mast cell activation, mediates type-1 allergic responses, one of the most powerful reactions of the immune system. However, mast cells activation is becoming increasingly linked to inflammatory, au…
Received 27 September 2007 14:50 UTC; Posted 28 September 2007
Posted to: Immunology, Molecular Cell Biology, Pharmacology, Bioinformatics
Differences in the gene expression profile of human monocytic cells activated by high and low affinity Fc-gamma-receptors.
Receptors for the constant (Fc) region of immunoglobulin G, play an important role in linking the humoral and cellular arms of immune response. Three different classes of receptors have been define…
Received 27 September 2007 14:42 UTC; Posted 28 September 2007
Posted to: Immunology, Molecular Cell Biology, Bioinformatics
Differential Gene Expression of Human Mast cell Activation Reveals Gene profiles of Innate and Adaptive Immunity.
High-density oligonucleotide microarray is a promising approach for high throughput analysis. It has been extensively used in many areas of biomedical research. Immunoglobulin E (IgE) mediated alle…
Received 27 September 2007 14:37 UTC; Posted 28 September 2007
Posted to: Immunology, Molecular Cell Biology, Pharmacology, Bioinformatics
