Immunology
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CD14 Modulates PI3K/AKT/p38-MAPK Licensing of Negative Regulators of TLR Signaling to Restrain Chronic Inflammation
Current thinking emphasizes the primacy of CD14 in facilitating TLR recognition of microbes to initiate proinflammatory signaling events and the importance of p38-MAPK in augmenting such responses….
Received 24 June 2008 18:09 UTC; Posted 25 June 2008
Posted to: Immunology, Microbiology
HBsAg-vectored DNA vaccines elicit concomitant protective responses to multiple CTL epitopes relevant in human disease.
Vaccines capable of controlling neoplastic and infectious diseases which depend on the cellular immune response for their resolution, have proven difficult to develop. We, and others, have previous…
Received 26 May 2008 05:03 UTC; Posted 27 May 2008
Posted to: Biotechnology, Cancer, Immunology
How gut sampling and microbial invasiveness/noninvasiveness provides mucosal immunity with a nonmolecular pattern means to distinguish commensals from pathogens: A review
Mucosal immunity distinguishes not only different microbial antigens but also separates those of pathogens from those of commensals. How this is done is unknown. The present view is that the pathog…
Received 16 May 2008 11:51 UTC; Posted 16 May 2008
Posted to: Immunology, Microbiology
IL-1 regulates the IL-23 response to wheat gliadin, the etiologic agent of Celiac Disease
Celiac disease (CD) is an autoimmune disease prevalent in ~1% of the general population. CD is unique because both the major genetic (Human Leukocyte Antigen-DQ2/DQ8 alleles) and etiologic factors …
Received 13 May 2008 16:55 UTC; Posted 13 May 2008
Posted to: Genetics & Genomics, Immunology
Immunity to self co-generates regulatory T cells
Immune responses to self are kept in check by tolerance mechanisms, including suppression by regulatory T cells (Tregs). The defective generation of Tregs specific for self-antigens may lead to aut…
Received 08 April 2008 23:43 UTC; Posted 09 April 2008
Posted to: Immunology
Effect of hyperglycemia on inflammatory markers in patients with Type 2 Diabetes
The role of inflammation in causation of both Diabetes and its complications has gained acceptance. Initially, hyperglycemia was thought to be the factor causing inflammation, but recently, obesity…
Received 05 February 2008 03:45 UTC; Posted 08 February 2008
Posted to: Immunology
Allicin from garlic suppresses TNF-α and augments IFN-γ expressions in monocyte cultures from patients with Vaginitis
Objective: We tried to explore beneficial effects of allicin- a natural antioxidant from garlic in the possible management of vaginitis. Methods: Peripheral blood mononuclear cells (PBMC’s) were …
Received 01 February 2008 09:49 UTC; Posted 01 February 2008
Posted to: Immunology, Microbiology, Molecular Cell Biology
Role and immunomodulatory profile of histamine receptors by H1 and H2 antagonists
The present study was designed to delineate the immunomodulatory role of histamine receptors (H1- and H2-) on induction of antibody response to sheep red blood cells (SRBC), as well as the antibody…
Received 29 January 2008 10:31 UTC; Posted 29 January 2008
Posted to: Immunology, Microbiology, Pharmacology
Modulation of interferon-α secretion by activated platelets in systemic lupus erythematosus.
Type I interferons play a key role in systemic lupus erythematosus (SLE) pathogenesis as an “IFN signature” is found in the majority of patients with active SLE. Immune complexes are internalized b…
Received 21 January 2008 17:10 UTC; Posted 22 January 2008
Posted to: Immunology
Interleukin-10 containing normal human serum inhibits granzyme B release but not perforin release from alloreactive and EBV-specific T cell clones
Interleukin-10 (IL-10), also known as cytokine synthesis inhibitory factor, has pleiotropic effects in immunoregulation and inflammation. It is capable of inhibiting synthesis of pro-inflammatory c…
Received 25 December 2007 06:30 UTC; Posted 26 December 2007
Posted to: Immunology
