Genetics & Genomics
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Novel mutations in the toll like receptor genes cause hyporesponsiveness to Mycobacterium avium subsp. paratuberculosis infection
Toll like receptors play a central role in the recognition of pathogen associated molecular patterns (PAMPs). Mutations in TLR1, TLR2 and TLR4 genes may change the PAMP reorganization ability which…
Received 11 December 2008 16:24 UTC; Posted 15 December 2008
Posted to: Genetics & Genomics, Immunology, Microbiology
Evidence of existence of totally different types of ribosomes in intermediate animals
In all organisms, messenger-directed protein synthesis is catalyzed by ribonucleoprotein particles called ribosomes. A ribosome is typically composed of one small and one large subunit which contai…
Received 07 December 2008 17:49 UTC; Posted 11 December 2008
Posted to: Genetics & Genomics, Microbiology, Molecular Cell Biology
Ageing as a price of cooperation and complexity: Self-organization of complex systems causes the ageing of constituent networks
The analysis of network topology and dynamics is increasingly used for the description of the structure, function and evolution of complex systems. Here we summarize key aspects of the evolvability…
Received 05 December 2008 11:47 UTC; Posted 05 December 2008
Posted to: Genetics & Genomics, Bioinformatics, Evolutionary Biology
The genetic equidistance result of molecular evolution is independent of mutation rates
The well-established genetic equidistance result shows that sister species are approximately equidistant to a simpler outgroup as measured by DNA or protein dissimilarity. The equidistance result …
Received 24 November 2008 19:59 UTC; Posted 25 November 2008
Posted to: Ecology, Genetics & Genomics, Bioinformatics
A population-based study of glutathione-S-transferase M1, T1 and P1 genotypes
A retrospective study on healthy, unrelated subjects was conducted in order to estimate population glutathione-S-transferases (GST) genotype frequencies in Slovak population of men and compare our …
Received 24 November 2008 07:11 UTC; Posted 24 November 2008
Posted to: Cancer, Genetics & Genomics
Statistical Modeling of Epistasis and Linkage Decay using Logic Regression
Logic regression has been recognized as a tool that can identify and model non-additive genetic interactions using Boolean logic groups. Logic regression, TASSEL-GLM and SAS-GLM were compared for a…
Received 18 November 2008 19:29 UTC; Posted 20 November 2008
Posted to: Genetics & Genomics, Bioinformatics
Tumor induction by disruption of the Dnmt1, PCNA and UHRF1 interactions.
The low level of DNA methylation in tumors compared to the level of DNA methylation in their normal-tissue counterparts or global DNA hypomethylation was one of the first epigenetic alterations to …
Received 13 November 2008 00:19 UTC; Posted 13 November 2008
Posted to: Genetics & Genomics
Competent intermediate hosts and genetic re-assortment: what does the ferret and raccoon model tell us about influenza pandemic risk?
Avian influenza virus (AI) strains such as H5N1 and H9N2 are endemic among birds and poultry globally and mainly within Eurasia. Human cases have been reported yet the transmission among humans has…
Received 12 November 2008 01:33 UTC; Posted 13 November 2008
Posted to: Genetics & Genomics, Immunology
Decrease in gyrase A protein expression in E. coli cells inhibited by antisense ribozymes
RNase P complexed with external guide sequence (EGS) represents a novel nucleic-acid-based gene interference approach to modulate gene expression. Nucleic acid-based gene interference technologies …
Received 17 October 2008 20:07 UTC; Posted 21 October 2008
Posted to: Genetics & Genomics
Nucleotide repeats in mitochondrial genome determine human lifespan
Direct nucleotide repeats can facilitate deletions of segments of mitochondrial genome1, leading to a wide range of neuromuscular disorders1,2 as well as aging2,3 in humans. We hypothesized that th…
Received 15 October 2008 08:02 UTC; Posted 17 October 2008
Posted to: Genetics & Genomics, Bioinformatics, Evolutionary Biology
