Genetics & Genomics
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Emergence and Fixing of Antiviral Resistance in Influenza A Via Recombination and Hitch Hiking
The dramatic rise of oseltamivir resistance in the H1N1 serotype in the 2007/2008 season and the fixing of H274Y in the 2008/2009 season has raised concerns regarding individuals at risk for season…
Received 29 January 2009 21:07 UTC; Posted 10 February 2009
Posted to: Biotechnology, Genetics & Genomics, Immunology
Analysis of Endocrine Disruption in Southern California Coastal Fish using an Aquatic Multi-Species Microarray
BACKGROUND: Endocrine disruptors include plasticizers, pesticides, detergents and pharmaceuticals. Turbot and other flatfish are used to characterize the presence of chemicals in the marine envir…
Received 28 January 2009 02:08 UTC; Posted 02 February 2009
Posted to: Developmental Biology, Ecology, Genetics & Genomics, Earth & Environment
Bias in culture-independent assessments of microbial biodiversity in the global ocean
On the basis of 16S rRNA gene sequencing, the SAR11 clade of marine bacteria has almost universal distribution, being detected as abundant sequences in all marine provinces. Yet SAR11 sequences are…
Received 27 January 2009 09:23 UTC; Posted 29 January 2009
Posted to: Ecology, Genetics & Genomics, Microbiology
Proof of principle for shotgun DNA mapping by unzipping
Ability to map polymerases and nucleosomes on chromatin is important for understanding the impact of chromatin remodeling on key cellular processes. Current methods (such as ChIP and ChIP-chip) ha…
Received 20 January 2009 23:52 UTC; Posted 21 January 2009
Posted to: Biotechnology, Genetics & Genomics
Nucleosome-mediated cooperativity between transcription factors
Cooperative binding of transcription factors (TFs) to cis-regulatory regions (CRRs) is essential for precision of gene expression in development and other processes. The classical model of cooperat…
Received 16 January 2009 23:21 UTC; Posted 21 January 2009
Posted to: Developmental Biology, Genetics & Genomics, Molecular Cell Biology, Bioinformatics
Inverse relationship between genetic diversity and epigenetic complexity
Early studies of molecular evolution revealed a correlation between genetic distance and time of species divergence. This observation provoked the molecular clock hypothesis and in turn the ‘Neutr…
Received 13 January 2009 19:33 UTC; Posted 15 January 2009
Posted to: Genetics & Genomics, Bioinformatics, Evolutionary Biology
Narrow genetic and apparent phenetic diversity in Jatropha curcas: initial success with generating low phorbol ester interspecific hybrids
Due to the increasing popularity of Jatropha curcas as a feedstock for biodiesel, generating non-toxic and high yielding varieties of the plant requires genotypic characterization towards identifyi…
Received 13 January 2009 09:17 UTC; Posted 16 January 2009
Posted to: Biotechnology, Ecology, Genetics & Genomics, Earth & Environment, Plant Biology
Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to altered dysbindin-1 gene expression
DTNBP1 (dystrobrevin binding protein 1) remains one of the top candidate genes in schizophrenia. Reduced expression of this gene and the protein it encodes, dysbindin-1, has been reported in the do…
Received 13 January 2009 01:19 UTC; Posted 13 January 2009
Posted to: Genetics & Genomics, Molecular Cell Biology, Neuroscience
Computational methods in cancer gene networking
In the past few years, many high-throughput techniques have been developed and applied to biological studies. These techniques such as “next generation” genome sequencing, chip-on-chip, microarray …
Received 30 December 2008 19:47 UTC; Posted 06 January 2009
Posted to: Cancer, Genetics & Genomics, Bioinformatics
DNA Genealogy, Mutation Rates, and Some Historical Evidences Written in Y-Chromosome
Origin of peoples in a context of DNA genealogy is an assignment of them to a particular tribe (all members of which belong to a certain haplogroup) or its branch (a lineage), initiated in a geneal…
Received 29 December 2008 23:14 UTC; Posted 30 December 2008
Posted to: Genetics & Genomics
