Genetics & Genomics
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The hotspot conversion paradox
The contradiction between the long-term persistence of the chromosomal hotspots that initiate meiotic recombination and the self-destructive mechanism by which they act strongly suggests that our u…
Received 17 August 2009 20:07 UTC; Posted 18 August 2009
Posted to: Genetics & Genomics, Evolutionary Biology
The joys and perils of recombination – The hotspot conversion paradox and the evolution of recombination
The contradiction between the long-term persistence of the chromosomal hotspots that initiate meiotic recombination and the self-destructive mechanism by which they act strongly suggests that our u…
Received 21 August 2009 20:11 UTC; Posted 21 August 2009
Posted to: Genetics & Genomics, Evolutionary Biology
Adverse Effects of Trichothiodystrophy DNA Repair and Transcription Gene Abnormalities on Human Fetal Development
The effects of DNA repair and transcription genes in human prenatal life have never been studied. Trichothiodystrophy (TTD) is a rare (affected frequency of 10-6) recessive disorder caused by mut…
Received 08 August 2009 21:45 UTC; Posted 11 August 2009
Posted to: Developmental Biology, Genetics & Genomics
Data Mining for Simple Sequence Repeats in Oil Palm Expressed Sequence Tags
Expressed Sequence Tags or ESTs are small pieces of DNA sequence that are generated by sequencing either one or both ends of an expressed gene. ESTs provide researchers with a quick and inexpensive…
Received 08 August 2009 12:55 UTC; Posted 10 August 2009
Posted to: Genetics & Genomics, Bioinformatics
Gender differences in a Drosophila transcriptomic model of chronic pentylenetetrazole induced behavioral deficit
A male Drosophila model of locomotor deficit induced by chronic pentylenetetrazole (PTZ), a proconvulsant used to model epileptogenesis in rodents, has recently been described. Antiepileptic drugs …
Received 25 July 2009 08:04 UTC; Posted 27 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
A Drosophila systems model of withdrawal from chronic pentylenetetrazole relevant in post-epileptogenesis
Rodent kindling induced by pentylenetetrazole (PTZ) is an established model of epileptogenesis and antiepileptic drug (AED) testing. Recently, a Drosophila systems model has been described in which…
Received 21 July 2009 16:19 UTC; Posted 21 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
A novel Drosophila transcriptomic and behavioral model detects potassium chloride with therapeutic potential
In a newly described Drosophila model, two of the five antiepileptic drugs (AEDs) tested, sodium valproate (NaVP) and levetiracetam (LEV), not ethosuximide (ETH), gabapentin (GBP) and vigabatrin …
Received 14 July 2009 15:23 UTC; Posted 17 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
A Study on the Origin of Peroxisomes: Possibility of Actinobacteria Symbiosis
Withdrawn
Received 13 July 2009 06:05 UTC; Posted 16 July 2009
Posted to: Genetics & Genomics, Evolutionary Biology
A novel Drosophila post-genomic CNS drug discovery model detects tetraethylammonium chloride with therapeutic potential
A Drosophila behavioral and transcriptomic model of locomotor plasticity induced by chronic pentylenetetrazole (PTZ) has recently been developed. In this model, two of the five antiepileptic drug…
Received 10 July 2009 11:55 UTC; Posted 10 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
Transcriptomic analysis implicates ribosomal and energy metabolic pathways in antiepileptic drug action in a Drosophila model
Mechanisms of long term action of antiepileptic drugs (AEDs), used in treating epilepsy and many other neurological and psychiatric disorders, are poorly understood. Recently, a novel Drosophila tr…
Received 03 July 2009 14:57 UTC; Posted 07 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
