Genetics & Genomics
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Swine Influenza A Evolution via Recombination – Genetic Drift Reservoir
The looming influenza pandemic has focused attention1-4 on the rapid evolution of H5N1 and other human and avian serotypes. The basic tenets of influenza genetics5 define gradual changes as dr…
Received 07 July 2007 03:02 UTC; Posted 10 July 2007
Posted to: Ecology, Genetics & Genomics
ProbCD: enrichment analysis accounting for categorization uncertainty
As in many other areas of science, systems biology makes extensive use of statistical association and significance estimates in contingency tables, a type of categorical data analysis known in this…
Received 06 July 2007 04:45 UTC; Posted 06 July 2007
Posted to: Biotechnology, Genetics & Genomics, Bioinformatics
Estimation of the Multiple Testing Burden for Genomewide Association Studies of Common Variants
Genomewide association studies are an exciting strategy in genetics, recently becoming feasible. While pioneering studies are being underway, it is already clear that the analytic issue of determin…
Received 05 July 2007 14:54 UTC; Posted 05 July 2007
Posted to: Genetics & Genomics, Bioinformatics
Promoter regions of many neural- and nutrition-related genes have experienced positive selection during human evolution
Surveys of protein-coding sequences for evidence of positive selection in humans and chimpanzees have flagged surprisingly few genes known to be involved in neural or nutritional processes, despite…
Received 18 June 2007 21:04 UTC; Posted 13 July 2007
Posted to: Genetics & Genomics, Bioinformatics, Evolutionary Biology
PharmGKB: Capturing knowledge to catalyze pharmacogenomics research
This is a powerpoint presentation made initially at the Cold Spring Harbor meeting on Pharmacogenomics, November 2006. It discusses the PharmGKB (http://www.pharmgkb.org/) and how we are building …
Received 30 November 2006 07:29 UTC; Posted 30 November 2006
Posted to: Biotechnology, Genetics & Genomics, Pharmacology
