Genetics & Genomics
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Telomeres in Evolution and Development from Biosemiotic Perspective
Whereas telomeres protect terminal ends of linear chromosomes, telomerases identify natural chromosome ends being different from broken DNA. Although telomeres play a crucial role in the linear chr…
Received 11 November 2007 17:47 UTC; Posted 12 November 2007
Posted to: Genetics & Genomics, Evolutionary Biology
Discovery of the Principal Cystic Fibrosis Mutation (F508del) in Ancient DNA from Iron Age Europeans
The most common, life-threatening autosomal recessive disease of Europeans and Euro-Americans, cystic fibrosis (CF), occurs predominately in patients with the F508del mutation.1 Although F508del is…
Received 29 October 2007 17:17 UTC; Posted 29 October 2007
Posted to: Genetics & Genomics, Evolutionary Biology
A Simple, Rapid Method for Extracting Large Plasmid DNA from Bacteria
We are studying the lateral transfer of transmissible antibiotic resistance plasmids among stream bacteria impacted by fecal runoff from poultry and cattle. Such plasmids are typically large (ca. 4…
Received 23 October 2007 21:58 UTC; Posted 24 October 2007
Posted to: Biotechnology, Genetics & Genomics, Microbiology
EvolveAGene 3: A DNA coding sequence evolution simulation program
EvolveAGene 3 is a realistic coding sequence simulation program that separates mutation from selection and allows the user to set selection conditions, including variable regions of selection inten…
Received 16 October 2007 19:00 UTC; Posted 16 October 2007
Posted to: Ecology, Genetics & Genomics, Bioinformatics, Evolutionary Biology
Transient-mediated fate determination in a transcriptional circuit of HIV
Steady-state behavior and bistability have been proposed as mechanisms for decision-making in gene circuits. However, transient gene expression has also been proposed to control cell fate with the …
Received 30 September 2007 17:17 UTC; Posted 01 October 2007
Posted to: Biotechnology, Genetics & Genomics, Molecular Cell Biology
Diagnostic robustness of DNA microarrays in the classification of acute leukemia
Countless statistical methods have been described for the analysis of DNA microarrays, and each yields distinct results. This raises the question whether DNA microarrays are robust diagnostic tools…
Received 20 September 2007 15:34 UTC; Posted 26 September 2007
Posted to: Biotechnology, Cancer, Genetics & Genomics, Molecular Cell Biology, Pharmacology, Bioinformatics
DNA expression microarrays may be the wrong tool to identify biological pathways
DNA microarray expression signatures are expected to provide new insights into patho- physiological pathways. Numerous variant statistical methods have been described for each step of the signal an…
Received 18 September 2007 13:09 UTC; Posted 19 September 2007
Posted to: Biotechnology, Genetics & Genomics, Molecular Cell Biology, Pharmacology, Bioinformatics
Concurrent Acquisition of a Single Nucleotide Polymorphism in Diverse Influenza H5N1 Clade 2.2 Sub-clades
Highly pathogenic Influenza A H5N1 was first identified in Guangdong Province in 1996, followed by human cases in Hong Kong in 1997. The number of confirmed human cases now exceeds 300, and the ass…
Received 10 September 2007 12:42 UTC; Posted 12 September 2007
Posted to: Biotechnology, Chemistry, Ecology, Genetics & Genomics, Immunology, Microbiology, Bioinformatics
Aggregation of Single Nucleotide Polymorphisms in a Human H5N1 Clade 2.2 Hemagglutinin
The rapid evolution of the H5N1 serotype of avian influenza has been explained by a mechanism involving the selection of single nucleotide polymorphisms generated by copy errors. The recent emerge…
Received 10 September 2007 09:26 UTC; Posted 12 September 2007
Posted to: Genetics & Genomics, Evolutionary Biology
Mushroom-bodies mediate hierarchical interactions between fact- and skill-learning in Drosophila
Different brain circuits mediate the acquisition of skills and habits (via operant/instrumental learning) and the acquisition of facts (via classical/Pavlovian learning). Realistic learning situati…
Received 04 September 2007 09:03 UTC; Posted 04 September 2007
Posted to: Genetics & Genomics, Neuroscience
