Genetics & Genomics
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The genetics of colored sequence synesthesia: Evidence of linkage to chromosome 16q and genetic heterogeneity for the condition
Synesthesia is a perceptual condition in which normal sensory stimulation can trigger anomalous sensory experiences. For example, synesthetes may experience colors in response to sounds, tastes in …
Received 19 November 2009 17:56 UTC; Posted 20 November 2009
Posted to: Genetics & Genomics, Neuroscience
9aaTAD Prediction result (2006)
Recently reported, 9aaTAD transcription factors p53, VP16, MLL/ALL, E2A, HSF1, NF-IL6, NFAT1 and NF-kB interact directly with the general coactivator CBP/p300 aside from already referred TAF9. All …
Received 18 November 2009 15:27 UTC; Posted 20 November 2009
Posted to: Genetics & Genomics
Reacquainting two cultures. Preventing a de-elsification of European nutrigenomics?
Sir Charles Snow, being a writer and a scientist, felt that he “was moving among two groups – comparable in intelligence, identical in race, not grossly different in social origin, earning about th…
Received 17 November 2009 10:41 UTC; Posted 17 November 2009
Posted to: Genetics & Genomics
Rsp5 promotes Gene Activation mediated by 9aaTAD Transcription Factors Oaf1 and Gal4
Nine-amino-acid transactivation domain, 9aaTAD, defines a large superfamily of yeast and mammals transcription factors. The transactivation of the 9aaTAD has been addressed to multiple general co-a…
Received 11 November 2009 23:04 UTC; Posted 16 November 2009
Posted to: Genetics & Genomics, Molecular Cell Biology
The cultural epigenetics of psychopathology: The missing heritability of complex diseases found?
We extend a cognitive paradigm for gene expression to the epigenetic epidemiology of mental disorders, recognizing the fundamental role that culture plays in human biology as another heritage mecha…
Received 11 November 2009 17:52 UTC; Posted 11 November 2009
Posted to: Developmental Biology, Genetics & Genomics, Neuroscience
Are endocannabinoid type 1 receptor gene (CNR1) polymorphisms associated with obesity and metabolic syndrome in postmenopausal Polish women?
Objective: The aim of this study was to determine whether genetic variation at the cannabinoid receptor-1 (CNR1) locus could have an effect on adiposity, fat distribution and obesity-related metabo…
Received 05 November 2009 01:29 UTC; Posted 06 November 2009
Posted to: Genetics & Genomics
9aaTADs mimic DNA to interact with a pseudo-DNA Binding Domain KIX of Med15 (Molecular Chameleons)
The KIX-domain of Gal11/MED15 was shown to interact with short transactivation domain of Pdr1 and Oaf1 (12 and 9 amino acids respectively) annotated to 9aaTAD family. Reported NMR data revealed a s…
Received 03 November 2009 21:11 UTC; Posted 05 November 2009
Posted to: Genetics & Genomics
Common Transactivation Motif 9aaTAD recruits multiple general co-activators TAF9, MED15, CBP and p300
More than 2000 transcription factors are involved in the human gene regulation to provide cellular function and development. Transactivation domain, TAD, mediates the interaction of transcription f…
Received 03 November 2009 12:30 UTC; Posted 05 November 2009
Posted to: Genetics & Genomics
MicroDNAs and Transcriptional Regulation
Synthetic "microDNAs (MIDs)"is a new class of ~ 20-25 nucleotide-long DNAs capable of repressing the activity of the target gene at the level of transcription by mechanisms that have not …
Received 04 November 2009 08:33 UTC; Posted 04 November 2009
Posted to: Cancer, Genetics & Genomics, Molecular Cell Biology
No evidence for a recent genetic bottleneck in the endangered Sheko cattle breed (African Bos taurus) revealed by microsatellite analysis
Sheko is African taurine cattle, valued for its milk yield, adaptation to humid tsetse infested environment and trypanotolerance. We used 30 microsatellite markers in analyzing 30 DNA samples. We f…
Received 30 October 2009 14:01 UTC; Posted 03 November 2009
Posted to: Genetics & Genomics
